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NUDC Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA906015A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, K562 whole cell lysate, 293T whole cell lysate, A549 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
      All lanes: NUDC antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39 kDa
      Observed band size: 45 kDa
  • 其他：

产品详情

  • 产品描述：

    The NUDC antibody CSB-RA906015A0HU is a rabbit IgG recombinant monoclonal antibody. The acquisition of the HUAC6 monoclonal antibody using the synthesized peptide derived from the human NUDC immunizes animals, the determination of the NUDC monoclonal antibody's DNA sequence, and the cloning of the DNA sequence into the plasmid and subsequent transfection into cell lines for expression are among the procedures used in its production. Affinity chromatography was used to purify this NUDC antibody. It has been put to the test in a variety of ways, including ELISA and WB. The NUDC protein from human, mouse, and rat samples reacts with this NUDC antibody.

    NUDC, a dynein-associated nuclear movement protein, forms a biochemical complex with dynein/dynactin complex components and is involved in nuclear translocation in proliferating neural progenitors and migrating neurons in culture. NUDC regulates microtubule structure at the midzone and midbody, which is important for mitosis and cytokinesis. By stabilizing cofilin 1 in an Hsp90-independent manner, NUDC modulates actin dynamics and cell motility.

  • Uniprot No.：
    Q9Y266
  • 基因名：
    NUDC
  • 别名：
    Nuclear migration protein nudC (Nuclear distribution protein C homolog), NUDC
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    A synthesized peptide derived from human NUDC
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    6C3
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
  • 基因功能参考文献：
    1. High expression of NUDC is associated with prostate cancer. PMID: 27959429
    2. the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells. PMID: 27035759
    3. NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis. PMID: 27074040
    4. NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression. PMID: 24069238
    5. Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma. PMID: 21473139
    6. NudC may be involved in the regulation of LIS1 stability by its chaperone function. PMID: 20675372
    7. separate binding sites on the Mpl receptor for TPO and hNUDC identified PMID: 20529857
    8. Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation. PMID: 19560457
    9. functions in mitosis and cytokinesis, in part by regulating microtubule organization at the midzone and midbody PMID: 12679384
    10. PLK1 phosphorylation of NudC plays an essential role in cytokinesis. PMID: 12852857
    11. Overexpression of NUDC inhibits prostatic neoplasm growth. PMID: 14676831
    12. In this study, we report the binding of hNUDC to the extracellular domain of the thrombopoietin receptor (Mpl) as detected by the yeast two-hybrid system, GST pull-down, and co-immunoprecipitation. PMID: 16088917
    13. NudC functions as both a substrate and a spatial regulator of Plk1 at the kinetochore to promote chromosome congression. PMID: 16860740
    14. hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation. PMID: 17658515
    15. hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways PMID: 18288130

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
  • 蛋白家族：
    NudC family
  • 组织特异性：
    Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
  • 数据库链接：

    HGNC: 8045

    OMIM: 610325

    KEGG: hsa:10726

    STRING: 9606.ENSP00000319664

    UniGene: Hs.263812