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Histone H1.0 Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA010087A0HU
  • 规格：
    ￥1320
  • 其他：

产品详情

  • 产品描述：

    The DNA sequence coding for the histone H1.0 monoclonal antibody produced from the animals with human synthesized histone H1.0 peptide immunization was cloned into the expression vector, which was further transfected into a cell line for in vitro expression. The product is the recombinant histone H1.0 monoclonal antibody. It specifically targets the human histone H1.0. It belongs to the rabbit IgG. The affinity-chromatography purification method was used to purify this histone H1.0 antibody. This histone H1.0 can be used in ELISA.

    Histone H1.0 is the most common variation at nucleoli-associated DNA domains (NADs), rDNA, and other repetitive sequences important in nucleolar structure. Histone H1.0 is a linker histone that plays a role in cell differentiation, stem cell maintenance, tumorigenesis, and extracellular vesicle (EV) formation, as well as affecting epigenetic and functional intra-tumor heterogeneity. H1.0 or its post-translational forms have also been discovered in EVs generated by cancer cells in culture, implying that these cells may avoid differentiation at least in part by discarding H1.0 via the EV route.

  • Uniprot No.：
    P07305
  • 基因名：
    H1F0
  • 别名：
    H1 histone family member 0 antibody; H1(0) antibody; H10 antibody; H10_HUMAN antibody; h1f0 antibody; H1FV antibody; Histone H1'' antibody; Histone H1(0) antibody; Histone H1.0 antibody; Histone H10 antibody; Histone H5 antibody; MGC5241 antibody; N-terminally processed antibody
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    1C7
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
  • 基因功能参考文献：
    1. H1.X moves more rapidly than other linker histones in vivo Domain swapping between H1.0 and H1.X suggests that the globular domain (GD) and C-terminal domain (CTD) of H1.X independently contribute to the dynamic behavior of H1.X. PMID: 27528617
    2. this study shows that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. PMID: 27708074
    3. The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 and H1c. PMID: 22334665
    4. nuclear transport of H1 histones requires a heterodimeric nuclear import receptor PMID: 12080050
    5. H1(0)histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression. PMID: 12149419

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  • 亚细胞定位：
    Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
  • 蛋白家族：
    Histone H1/H5 family
  • 数据库链接：

    HGNC: 4714

    OMIM: 142708

    KEGG: hsa:3005

    STRING: 9606.ENSP00000344504

    UniGene: Hs.745024