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CETP Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA005267A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA005267A0HU diluted at 1:115 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品描述：

    This is a recombinant monoclonal antibody against CETP. It is matched isotype control by rabbit IgG. The cloning of the human CETP DNA gene into the vector and subsequent transfection into the cell line for in vitro expression lead to the production of this CETP antibody. This CETP antibody can recognize human CETP protein. It is purified using affinity-chromatography and is recommended for ELISA and IHC applications.

    CETP is an enzyme responsible for moving cholesterol esters and triglycerides between VLDL, LDL, and HDL. It, therefore, plays an important role in blood lipid homeostasis. Plasma CETP results in free cholesterol accumulation on islets, contributing to beta-cell dysfunction. CETP inhibition thus could be a new protective strategy for dyslipidemia associated with diabetes and obesity.

  • Uniprot No.：
    P11597
  • 基因名：
  • 别名：
    BPIFF antibody; CETP antibody; CETP_HUMAN antibody; Cholesteryl ester transfer protein antibody; Cholesteryl ester transfer protein plasma antibody; HDLCQ10 antibody; Lipid transfer protein I antibody
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human CETP
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    2F1
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.
  • 基因功能参考文献：
    1. Studied frequency of two genetic polymorphisms of cholesteryl ester transfer protein (CETP) in a Mongolian population with essential hypertension. PMID: 28425253
    2. The I405V polymorphism in the CETP gene is strongly associated with ischemic stroke in a Polish population. PMID: 30078763
    3. CETP may play an important role in the development of atherosclerosis mainly by decreasing HDL-C levels and increasing the accumulation of macrophage-derived foam cells PMID: 29317793
    4. Our results show an association of this CETP variant at position +82 on HDL cholesterol, levels and adiposity parameters in obese subjects with diabetes mellitus type 2 PMID: 29280647
    5. Results demonstrate that CETP expression reduced HDL and increased non-HDL fractions. Also, exercise training reduced CETP plasma levels. These results reinforce the positive metabolic effects of exercise, and resolved a controversy about CETP response to exercise PMID: 29058169
    6. APOE4 carriers and the CETP genotype were associated with a decreased response to simvastatin therapy PMID: 28851085
    7. Meta-analysis of 6 case-control studies were identified with 1494 cases and 1370 controls. An association of cholesteryl ester transfer protein (CETP) TaqIB polymorphism with ischemic stroke (IS) was found in the 4 genetic models. In the subgroup analysis by ethnicity, similar risks were also observed in Asian population. CETP TaqIB polymorphism is associated with IS risk, and the B2 allele is a protective factor. PMID: 28648960
    8. The aggregation analysis revealed a higher correlation between siblings than between parent-offspring pairs representing the role of genetic factors in metabolic syndrome (MetS). In addition, the conditional logistic model with covariates showed that the linkage results between HDL_C and three markers, FTO (rs1558902 and rs7202116) and CETP(rs1864163) were significant. PMID: 29548861
    9. Regression analysis revealed significant risk for memory loss that are dependent on age and genetic variants like CETP. PMID: 28777751
    10. The -629C allele was significantly associated with an increased risk of Coronary heart disease in Caucasians, and this association may be mediated by its phenotypic regulation on circulating CETP and HDL-C. PMID: 27791990
    11. inhibitors, especially Torcetrapib and Anacetrapib, increased the binding ratios of the binary complexes (e.g., HDL-CETP and LDL-CETP) and decreased the binding ratios of the HDL-CETP-LDL ternary complexes. PMID: 28911944
    12. Studied association of Cholesterol Ester Transfer Protein (CETP) genetic polymorphisms with acute coronary syndrome; found the frequency of certain genotypes was significantly lower in unstable angina patients, compared with the control group PMID: 28387842
    13. Inhibiting cholesteryl ester transfer protein activity inhibits vascular smooth muscle cell proliferation, and reduces neointimal hyperplasia in an scavenger receptor-B1, PDZ domain-containing protein 1- and phosphatidylinositol-3-kinase/Akt-dependent manner. PMID: 29025709
    14. The rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms of CETP were associated with metabolic syndrome and its components among the Uyghur ethnic group. Complete linkage disequilibrium was found between two pairs of SNPs (rs3764261 and rs12149545, rs711752, and rs708272). PMID: 28629169
    15. CETP-inhibition, although effective in improving the lipid profile, is not associated with vascular protective effects as assessed by endothelial function. PMID: 28152406
    16. The study identified two polymorphisms with a higher risk of age-related macular degeneration development (AMD) and also a protective polymorphism for AMD. PMID: 28918250
    17. CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians (Meta-Analysis) PMID: 27608031
    18. Combined exposure to variants in the genes that encode the targets of CETP inhibitors and statins was associated with discordant reductions in LDL-C and apoB levels and a corresponding risk of cardiovascular events that was proportional to the attenuated reduction in apoB but significantly less than expected per unit change in LDL-C. PMID: 28846118
    19. Treatment of mildly hypercholesterolemic subjects with CETP inhibitor anacetrapib reduces Lp(a) levels by decreasing its production. PMID: 28729361
    20. Carriers of protein-truncating variants of CETP displayed higher high-density lipoprotein cholesterol and lower risk for coronary heart disease. PMID: 28506971
    21. Based on results from the study with a relatively large sample size, CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, the evidence is provided that this pharmacogenetic effect is independent of its association with baseline HDL-C levels. PMID: 27587472
    22. The rs1800775 [1.31 (1.22-1.42); p = 3.41E-12] in the CETP gene and rs359027 [1.26 (1.16-1.36); p = 2.55E-08] in the LMCD1 gene were significantly associated with LHDLC levels PMID: 26879886
    23. CETP modulates the distribution of spingosine-1-phosphate among lipoproteins, which affects the bioactivities of S1P. PMID: 28126827
    24. Anacetrapib treatment increases HDL apoA-I and CETP levels by decreasing the fractional clearance rate of each protein. PMID: 26966279
    25. Since expression of CETP has been shown to be positively correlated with the risk of CAD, higher frequency of "A" allele (patients: 22.69% vs.controls: 13%) reveals that c.*84G>A is a risk factor for CAD in South Indians PMID: 27768712
    26. CETP V405V genotype was associated with significantly enhanced HDL levels (P = 0.03), mostly owing to the female sex (P = 0.46 for males, P = 0.02 for females), whereas LDL and triglyceride levels were unchanged. PMID: 27439317
    27. The single nucleotide polymorphisms in lipoprotein lipase, ApoA5, and CETP were associated with serum triglycerides and HDL-cholesterol levels, but not with coronary artery disease in Pakistani population under study. PMID: 28143480
    28. Elevated CETP blood concentration was risk factor for coronary artery disease and correlates with pre beta1-high-density lipoprotein. PMID: 28073362
    29. Results show that the bound cholesteryl esters intraconvert between bent and linear conformations in the CETP core tunnel as a consequence of the high degree of conformational flexibility of the protein. PMID: 27445332
    30. Daily consumption of policosanol for 8 weeks resulted in lowered blood pressure, reduced serum TG level and CETP activity, and elevated HDL-C contents. PMID: 28259941
    31. serum CETP and PLTP activity in patients diagnosed with hypothyroidism, was examined. PMID: 27899788
    32. Elevated CETP Lipid Transfer Activity is Associated with the Risk of Venous Thromboembolism. PMID: 27169917
    33. it can be concluded that the effects of the CETP variation on LDL subfraction could change in cardiometabolic events such as coronary heart disease and statin therapy. PMID: 27900488
    34. Genetic variants in CETP associated with increased plasma high-density lipoprotein cholesterol raise the risk of intracerebral hemorrhage PMID: 27717122
    35. CETP Taq1B Polymorphisms are associated with Hyperlipidemia. PMID: 27590083
    36. The study has identified a novel ethnic-specific gene-gene interaction and suggested that the combination of cholesteryl ester transfer protein B1 allele and endothelial nitric oxide synthase 4a allele significantly increases the risk of coronary artery disease in Malays and Indians. PMID: 25667236
    37. Both PCSK9 levels and CETP activity were higher in patients with an increasing number of metabolic syndrome components PMID: 27488210
    38. Our results suggest that there is no significant association between CETP I405V polymorphism and the risk of coronary artery disease presence and severity PMID: 26773179
    39. Data show that polymorphisms of rs662799 and rs2266788 in APOA5 gene, rs320 in LPL gene and rs708272 in CETP gene had significant association with the effect of the lipid-lowering therapy via atorvastatin on ischemic stroke patients. PMID: 27415775
    40. Study provides no evidence for CETP gene rs708272 polymorphism association with metabolic syndrome despite its influence on its blood protein concentration. PMID: 27496123
    41. results showed that a hydrophobic tunnel inside CETP is sufficient to allow a CE molecule to completely transfer through the entire CETP within a predicted transfer time and at a rate comparable with those obtained through physiological measurements PMID: 27143480
    42. SNPs at the CETP, HNF4A and KLF14 locus are associated with HDL-C levels and type 2 diabetes (in female participants). PMID: 26670163
    43. Cholesteryl ester transfer between HDL and LDL lipoproteins does not require a ternary tunnel complex with CETP. PMID: 26876146
    44. No evidence for clinically relevant associations between several measures of body fat and serum CETP concentration. This finding implies that adipose tissue does not contribute to the CETP pool in serum. PMID: 26820801
    45. This is the first report on the association of these polymorphisms with Coronary artery disease (CAD) in Saudi Arabia. The rs5882 polymorphism (CETP) showed a significant association and therefore could be a promising marker for CAD risk PMID: 26936456
    46. A single-nucleotide polymorphism in the cholesteryl ester transfer protein (CETP) gene (isoleucine to valine; V405) is associated with slower memory decline and a lower risk of Alzheimer's disease. PMID: 27033407
    47. CETP per se has no impact on the glucose tolerance and tissue uptake, global insulin sensitivity and beta cell insulin secretion rates. PMID: 26758205
    48. Study suggests that the II genotype of the CETP I405V polymorphism is associated with significant abnormalities in gray matter microstructure compared to those with a V405 allele PMID: 26253899
    49. The cholesteryl ester transfer protein (CETP) rs3764261 variant was significantly associated with an increased risk of AMD PMID: 26503844
    50. The polymorphism of CETP genes rs708272, rs3764261, rs1800775, rs711752, rs12149545 was closely related to the dyslipidemia in the Xinjiang Uyghur and Kazakh ethnic groups; and the rs708272 T, rs3764261 T, rs711752 A, and rs12149545 A alleles could reduce risk of dyslipidemia in the Uyghur and Kazakh populations, however, the rs1800775 C allele showed risk factors PMID: 26694435

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  • 相关疾病：
    Hyperalphalipoproteinemia 1 (HALP1)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    BPI/LBP/Plunc superfamily, BPI/LBP family
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    HGNC: 1869

    OMIM: 118470

    KEGG: hsa:1071

    STRING: 9606.ENSP00000200676

    UniGene: Hs.89538