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wnt8 Antibody

  • 货号：
    CSB-PA340936LA01XBE
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Xenopus laevis wnt8 Polyclonal antibody
  • Uniprot No.：
    P28026
  • 基因名：
    wnt8
  • 别名：
    wnt8 antibody; Protein Wnt-8 antibody; XWnt-8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Xenopus laevis
  • 免疫原：
    Recombinant Xenopus laevis Protein Wnt-8 protein (23-358AA)
  • 免疫原种属：
    Xenopus laevis
  • 标记方式：
    Non-conjugated

    本页面中的产品，wnt8 Antibody (CSB-PA340936LA01XBE)，的标记方式是Non-conjugated。对于wnt8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA340936LB01XBE wnt8 Antibody, HRP conjugated ELISA
    FITC CSB-PA340936LC01XBE wnt8 Antibody, FITC conjugated
    Biotin CSB-PA340936LD01XBE wnt8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in ventral mesodermal patterning during embryogenesis. Mimics Nieuwkoop center activity. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with noggin and nuclear, sequence-specific DNA-binding protein xBra. None of these molecules causes dorsal mesoderm formation when expressed alone.
  • 基因功能参考文献：
    1. Data show that Noggin4 fine-tune the Wnt8 posterior-to-anterior gradient. PMID: 26973133
    2. EFHC1 domains are involved in ciliary localization, ciliogenesis, and the regulation of Wnt8a signaling PMID: 26783883
    3. Sulf1 inhibits the ability of Wnt8a to activate the canonical Wnt signalling pathway. PMID: 25681501
    4. study presents the structure of Xenopus Wnt8 (XWnt8) in complex with the mouse Fz8-cysteine-rich domain to a resolution of 3.25 A PMID: 22653731
    5. Xwnt8 directly initiates expression of labial Hox genes. PMID: 19623617
    6. Wnt8 conveyed by Frizzled-related proteins can activate canonical Wnt signalling despite the function of Frizzled-related proteins as Wnt inhibitors, suggesting a novel regulatory system for Wnts by sFRPs PMID: 19906850
    7. by performing gain- and loss-of-function of Wnt signaling experiments, we show that this pathway plays an important role not only in neural crest induction but also in the specification of the neural crest competence territory PMID: 14699582
    8. Wnt8 may stimulate a cellular phosphatase to dephosphorylate and activate CKIepsilon PMID: 14722104
    9. Molecular modeling of the complex between the xWNT8 protein and the CRD domain of mFZD8 PMID: 17506343
    10. Xwnt8-mediated posteriorization is restricted to the eye level and is independent of mesoderm formation. PMID: 18318733
    11. Fgf8a induces neural crest (NC) indirectly through the activation of Wnt8 in the paraxial mesoderm, which in turn promotes NC formation in the overlying ectoderm primed by Bmp antagonists. PMID: 18997112

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Wnt family
  • 数据库链接：

    KEGG: xla:397970

    UniGene: Xl.49