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pho Antibody

  • 货号：
    CSB-PA848344XA01DLU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: pho antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
  • 其他：

产品详情

  • Uniprot No.：
    Q8ST83
  • 基因名：
    pho
  • 别名：
    Polycomb protein PHO (Protein pleiohomeotic) (Transcription factor YY1 homolog) pho CG17743
  • 反应种属：
    Drosophila melanogaster (Fruit fly)
  • 免疫原：
    Recombinant Drosophila melanogaster (Fruit fly) pho protein (1-250aa )
  • 免疫原种属：
    Drosophila melanogaster (Fruit fly)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Protein G
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
  • 基因功能参考文献：
    1. Mutation in the protein-protein interaction domain (REPO domain) of Pho interferes with the dynamics of its interaction with Spt5. The transcriptional kinetics of the heat shock response is negatively affected by a mutation in the REPO domain of Pho PMID: 29208012
    2. Spt5 interacts both physically and genetically with the Polycomb Group (PcG) protein Pleiohomeotic (Pho) PMID: 23894613
    3. The TF homolog pair Pho/Yy1 seems to play very different roles in PcG targeting between Drosophila and mouse. PMID: 20353814
    4. Pleiohomeotic protein has a role in polycomb response element-mediated silencing for transcriptional repression PMID: 12370294
    5. This protein functions as a PcG protein in vivo. PMID: 12628927
    6. The mammalian transcription factor YY1 can function as a PcG protein in Drosophila resulting in transcriptional repression and correction of phenotypic defects caused by mutation of its homologue, Pleiohomeotic (PHO). PMID: 16052488
    7. Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) bind highly cooperatively to polycomb response elements PMID: 16077005
    8. grainyhead interacts genetically with pleiohomeotic in a transgene-based, pairing-dependent silencing assay PMID: 16449654
    9. YY1 sequences 201-226 are necessary and sufficient for Polycomb group transcriptional repression in vivo. PMID: 17158804
    10. These results suggest that pho functions in maintaining expression of genes involved in the formation of ventral appendages and the proximo-distal axis. PMID: 18495104
    11. Pho is a general component of the maintenance machinery, since the majority of Pc targets are also associated with Pho (Pleiohomeotic )binding. PMID: 18773083
    12. a DNA-binding complex requiring Pho is differentially regulated to facilitate epigenetic transcriptional memory of both the active and the repressed state PMID: 19029043

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: dme:Dmel_CG17743

    STRING: 7227.FBpp0088268

    UniGene: Dm.1406