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nrdA Antibody

  • 货号：
    CSB-PA355522HA01EVN
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Escherichia coli nrdA Polyclonal antibody
  • Uniprot No.：
    P00452
  • 基因名：
    nrdA
  • 别名：
    nrdA antibody; dnaF antibody; b2234 antibody; JW2228 antibody; Ribonucleoside-diphosphate reductase 1 subunit alpha antibody; EC 1.17.4.1 antibody; Protein B1 antibody; Ribonucleoside-diphosphate reductase 1 R1 subunit antibody; Ribonucleotide reductase 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Escherichia coli
  • 免疫原：
    Recombinant Escherichia coli Ribonucleoside-diphosphate reductase 1 subunit alpha protein (1-761AA)
  • 免疫原种属：
    Escherichia coli
  • 标记方式：
    Non-conjugated

    本页面中的产品，nrdA Antibody (CSB-PA355522HA01EVN)，的标记方式是Non-conjugated。对于nrdA Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA355522HB01EVN nrdA Antibody, HRP conjugated ELISA
    FITC CSB-PA355522HC01EVN nrdA Antibody, FITC conjugated
    Biotin CSB-PA355522HD01EVN nrdA Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
  • 基因功能参考文献：
    1. Elimination of 6 helicases lowered NrdA production further, whereas overexpression of any RNA helicase partially reversed the downregulation. UV stress completely reversed down-regulation of NrdA production PMID: 26574793
    2. The present results identifying a large, new set of E. coli mutator strains with mutations of nrdAB ribonucleotide reductase(RNR)confirm the important control that RNR exerts on the cellular mutation rate and provide novel insights into the RNR feedback regulatory mechanisms. PMID: 22417940
    3. RNR101 is unstable at 42 degrees C ; its degradation is prevented by rifampicin; inactivation of DnaA protein by allows chromosome replication in absence of rifampicin and suppresses nucleoid segregation and cell division defects seen in nrdA101 mutant at 42 degrees C PMID: 21527473
    4. The report three independent methods that establish that Y(356) is the predominant location (85-90%) of the radical, with the remaining 10-15% delocalized onto Y(731) and Y(730) in alpha2. PMID: 21967342
    5. The s propose that RecA is required to maintain the integrity of the reversed forks in the nrdA101 mutant under certain restrictive conditions, supporting the relationship between DNA replication and recombination enzymes. PMID: 21441507
    6. The s show that the binding of DnaA on the NrdAB promoter can either activate or repress transcription as a function of its concentration and its nucleotide-bound state. PMID: 20487274
    7. analysis of key residues in the dimerization process of ribonucleotide reductase protein R1 PMID: 15699052
    8. There is an indirect relationship between NDP reductase and the chromosome segregation machinery through the maintenance of the proposed replication hyperstructure. PMID: 17124544
    9. it is proposed that an altered NDP reductase, as a component of the replication machinery, impairs the progression of the replication fork, contributing to the lengthening of the C period in the nrdA101 mutant at the permissive temperature PMID: 17322311

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  • 蛋白家族：
    Ribonucleoside diphosphate reductase large chain family
  • 数据库链接：

    KEGG: ecj:JW2228

    STRING: 316385.ECDH10B_2393