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nikR Antibody

  • 货号：
    CSB-PA363929HA01EOD
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Escherichia coli nikR Polyclonal antibody
  • Uniprot No.：
    P0A6Z6
  • 基因名：
    nikR
  • 别名：
    nikR antibody; yhhG antibody; b3481 antibody; JW3446Nickel-responsive regulator antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Escherichia coli
  • 免疫原：
    Recombinant Escherichia coli Nickel-responsive regulator protein (1-133AA)
  • 免疫原种属：
    Escherichia coli
  • 标记方式：
    Non-conjugated

    本页面中的产品，nikR Antibody (CSB-PA363929HA01EOD)，的标记方式是Non-conjugated。对于nikR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA363929HB01EOD nikR Antibody, HRP conjugated ELISA
    FITC CSB-PA363929HC01EOD nikR Antibody, FITC conjugated
    Biotin CSB-PA363929HD01EOD nikR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
  • 基因功能参考文献：
    1. Structural basis of low-affinity nickel binding to the nickel-responsive transcription factor NikR from Escherichia coli PMID: 20704276
    2. localized this Ni(II) site to a region at the interface between the metal- and DNA-binding domains and identified His48 and His110 as residues that participate in the low-affinity Ni(II)-binding response PMID: 20583753
    3. Mutagenesis and cation exchange experiments reveal that K(+) is a critical structural component for the activation of Ni(II)-responsive DNA binding by NikR. PMID: 20088519
    4. This data sheds light on the Ni(II)-selective conformational changes that allow NikR to bind DNA optimally and repress transcription of the nik operon. PMID: 16133200
    5. Two crystal structures of nickel-activated E. coli NikR were reported. PMID: 16945905
    6. NikR response is specific to nickel in vivo. PMID: 17397155
    7. Results examine a series of residue interrelationships that describe an allosteric communication pathway between the Ni(2+)- and DNA-binding sites of NikR, which are separated by 40 A. PMID: 18433769

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  • 蛋白家族：
    Transcriptional regulatory CopG/NikR family
  • 数据库链接：

    KEGG: ecj:JW3446

    STRING: 316385.ECDH10B_3655