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mes-2 Antibody

  • 货号：
    CSB-PA515708XA01CXY
  • 规格：
    ￥880
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:mes-2 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 30.6 kDa
      Observed band size: 32 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Caenorhabditis elegans mes-2 Antibody Polyclonal antibody
  • Uniprot No.：
    O17514
  • 基因名：
    mes-2 Antibody
  • 别名：
    Histone-lysine N-methyltransferase mes-2 (EC 2.1.1.43) (E(z) homolog) (Maternal-effect sterile protein 2) mes-2 R06A4.7
  • 宿主：
    Rabbit
  • 反应种属：
    Caenorhabditis elegans
  • 免疫原：
    Recombinant Caenorhabditis elegans mes-2 protein (281-525aa)
  • 免疫原种属：
    Caenorhabditis elegans
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Polycomb group (PcG) protein. Catalytic subunit of a the mes-2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells. Required for small-RNA-induced H3K27 trimethylation. Involved in the negative regulation of lifespan in a germline-independent fashion.
  • 基因功能参考文献：
    1. mes-2 mutants suppress mab-3. PMID: 12791262
    2. mes-2 represses Hox expression, causing anteroposterior transformations and disrupts Hox-dependent neuroblast migration. PMID: 12791273
    3. The SET domain of MES-2 functions as a histone h3 methyltransferase in X chromosome inactivation. PMID: 15380065
    4. mes-2 orchestrates large-scale changes in chromatin organization and gene expression to promote the timely loss of developmental plasticity. PMID: 19460346
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
  • 组织特异性：
    In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells. Expressed in the hypoderm.
  • 数据库链接：

    KEGG: cel:CELE_R06A4.7

    STRING: 6239.R06A4.7

    UniGene: Cel.19654