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fliC Antibody

  • 货号：
    CSB-PA09734A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品描述：
    fliC polyclonal antibody CSB-PA09734A0Rb was produced in the rabbit immunized by using the Recombinant Escherichia coli Flagellin protein (2-498AA) as the immunogen. The target protein fliC is the subunit protein which polymerizes to form the filaments of bacterial flagella. Studies indicate that toll-like receptor 5 (TLR5) specifically interacts with flagellin, and is useful as an analytical recognition element for low concentrations of flagellin. Flagellin subunit FliC function as adhesins to piglet epithelial cells invasion.
    This Rabbit anti-Escherichia coli (strain K12) fliC Polyclonal antibody was tested in the ELISA. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the fliC proteins of Escherichia coli-origin and may be used to detect the endogenous levels of fliC protein.
  • 产品名称：
    Rabbit anti-Escherichia coli fliC Polyclonal antibody
  • Uniprot No.：
    P04949
  • 基因名：
    fliC
  • 别名：
    fliC antibody; flaF antibody; hag antibody; b1923 antibody; JW1908Flagellin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Escherichia coli
  • 免疫原：
    Recombinant Escherichia coli Flagellin protein (2-498AA)
  • 免疫原种属：
    Escherichia coli
  • 标记方式：
    Non-conjugated

    本页面中的产品，fliC Antibody (CSB-PA09734A0Rb)，的标记方式是Non-conjugated。对于fliC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA09734B0Rb fliC Antibody, HRP conjugated ELISA
    FITC CSB-PA09734C0Rb fliC Antibody, FITC conjugated
    Biotin CSB-PA09734D0Rb fliC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
  • 基因功能参考文献：
    1. Studies indicate that toll-like receptor 5 (TLR5) specifically interacts with flagellin, and is useful as an analytical recognition element for low concentrations of flagellin. PMID: 24881544
    2. Flagellin subunit FliC function as adhesins to piglet epithelial cells invasion. PMID: 23746569
    3. Results showed a reproducible and clear cut classification with molecular polymorphism of gene rfb cluster and flagella gene fliC. PMID: 19656466
    4. Flagellin in E. coli Nissle 1917 is the major stimulatory factor of human beta-defensin. PMID: 17283097
    5. Relations between the diversity of the fliC gene conditioning flagellum protein in E. coli and the source of the strain origin are presented PMID: 17702465
    6. Flagellin expression by uropathogenic Escherichia coli coincides with ascension of the ureters and colonization of the kidney. PMID: 17925449
    7. This study demonstrated that infection of intestinal epithelial cells by A/E pathogens can trigger an array of proinflammatory responses from epithelial cells through both FliC-dependent and -independent pathways. PMID: 18227166
    8. Insertion of Cys-derived thiol residues in the E. coli FliC protein increased Au(III) sorption and reduction onto the surface of the flagellar filament and resulted in the production of stabilized Au(0) nanoparticles of approximately 20-50 nm diameter. PMID: 18819156
    9. Binding of a fliC(H7) mutant O157 strain to rectal epithelium was significantly reduced as was binding of the flagellated wild-type strain following incubation with H7-specific antibodies. PMID: 19016776
    10. Increased IL-8 levels mainly depended on flagellin expression as fliC-negative EPEC did not elicit a significant IL-8 response despite increased mucosal colonization compared with wild-type EPEC. PMID: 19134113
    11. FliC is secreted by the LEE-encoded type III secretion system and stimulates TLR5 signalling but does not confer motility. PMID: 19200386

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  • 亚细胞定位：
    Secreted. Bacterial flagellum.
  • 蛋白家族：
    Bacterial flagellin family
  • 数据库链接：

    KEGG: ecj:JW1908

    STRING: 316407.1736591