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ZRSR2 Antibody

  • 货号：
    CSB-PA618014LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA618014LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The product CSB-PA618014LA01HU is a polyclonal antibody raised in the rabbit with a peptide covering amino acids 191-372 of the human ZRSR2 protein immunized. The ZRSR2 antibody exists as an unconjugated IgG. It can specifically bind to the ZRSR2 protein, a splicing factor involved in the recognition of 3′-intron splice sites during the early stages of spliceosome assembly. This anti-ZRSR2 antibody has undergone quality tested for use in common research applications, including ELISA, WB, IHC, and IF. Its purity is over 95% using protein G purified. And it is reactive with human and mouse samples.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZRSR2 Polyclonal antibody
  • Uniprot No.：
    Q15696
  • 基因名：
    ZRSR2
  • 别名：
    CCCH type zinc finger antibody; CCCH type zinc finger; RNA binding motif and serine/arginine rich protein 2 antibody; MGC142014 antibody; MGC142040 antibody; Renal carcinoma antigen NY REN 20 antibody; Renal carcinoma antigen NY-REN-20 antibody; RNA-binding motif and serine/arginine rich protein 2 antibody; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit related protein 2 antibody; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1 like 2 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2 antibody; U2AF1 RS2 antibody; U2AF1L2 antibody; U2AF1RS2 antibody; U2AF35-related protein antibody; U2AFM_HUMAN antibody; URP antibody; Zinc finger-; CCCH domain-; and RNA-binding motif-containing serine/arginine-rich protein 2 antibody; Zrsr2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 protein (191-372AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ZRSR2 Antibody (CSB-PA618014LA01HU)，的标记方式是Non-conjugated。对于ZRSR2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA618014LB01HU ZRSR2 Antibody, HRP conjugated ELISA
    FITC CSB-PA618014LC01HU ZRSR2 Antibody, FITC conjugated
    Biotin CSB-PA618014LD01HU ZRSR2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.
  • 基因功能参考文献：
    1. We conclude that the common clinical features of patients with an isolated mutation of ZRSR2 are a macrocytic anemia without leukopenia, thrombocytopenia or an increase in marrow blast percentage PMID: 28942350
    2. ZRSR2 has a role in RNA splicing; dysregulated splicing of U12-type introns is a characteristic feature of ZRSR2 mutations in myelodysplastic syndrome PMID: 25586593
    3. Data show that through recognition of a common splicing element, Urp facilitates distinct steps of U2- and U12-type intron splicing. PMID: 21041408
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 23019

    OMIM: 300028

    KEGG: hsa:8233

    STRING: 9606.ENSP00000303015

    UniGene: Hs.171909