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ZP2 Antibody

  • 货号：
    CSB-PA027120ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ZP2 antibody at 3.06μg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Lane 4: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 83, 82 kDa
      Observed band size: 83 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA027120ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA027120ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZP2 Polyclonal antibody
  • Uniprot No.：
    Q05996
  • 基因名：
    ZP2
  • 别名：
    OTTHUMP00000115849 antibody; Processed zona pellucida sperm-binding protein 2 antibody; Zona pellucida glycoprotein 2 antibody; zona pellucida glycoprotein ZP2 antibody; Zona pellucida protein A antibody; Zp-2 antibody; ZP2 antibody; ZP2_HUMAN antibody; ZPA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zona pellucida sperm-binding protein 2 protein (651-745AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
  • 基因功能参考文献：
    1. Mutations in ZP2 and ZP3 have dosage effects which can cause female infertility in humans. PMID: 28646452
    2. ZP2(51-149) sperm-binding domain is necessary for human gamete recognition and penetration through the zona pellucida. PMID: 24934154
    3. Studies indicate that eggs from mice lacking an ortholog of ZP2 do not contain a zona pellucida (ZP), and the mice are completely infertile due to a severely reduced number of ovulated eggs in their oviducts. PMID: 23417405
    4. observed sequence variations in exons of ZP2 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
    5. Of all zona pellucida (ZP) proteins, recombinant human ZPA demonstrates the highest binding activity toward acrosin PMID: 15950651
    6. Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns. PMID: 16407501
    7. ZP proteins were detected in both the oocyte and the granulosa cells as early as the primordial follicle stage in the human. The detection of ZP proteins in the quiescent primordial follicle suggests that these proteins have been present since oogenesis. PMID: 18033806

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  • 亚细胞定位：
    [Processed zona pellucida sperm-binding protein 2]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ZP domain family, ZPA subfamily
  • 组织特异性：
    Expressed in occytes(at protein level).
  • 数据库链接：

    HGNC: 13188

    OMIM: 182888

    KEGG: hsa:7783

    STRING: 9606.ENSP00000219593

    UniGene: Hs.73982