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ZP1 Antibody

  • 中文名称：
    ZP1兔多克隆抗体
  • 货号：
    CSB-PA008280
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of LOVO cells using ZP1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P60852
  • 基因名：
    ZP1
  • 别名：
    MGC87693 antibody; Processed zona pellucida sperm-binding protein 1 antibody; zona pellucida glycoprotein 1 (sperm receptor) antibody; Zona pellucida glycoprotein 1 antibody; zona pellucida protein 1 antibody; Zp 1 antibody; Zp-1 antibody; Zp1 antibody; ZP1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ZP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
  • 基因功能参考文献：
    1. this study identified a homozygous frameshift mutation in ZP1 in six family members with a form of infertility with an autosomal recessive mode of inheritance. PMID: 24670168
    2. observed sequence variations in exons of ZP1 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
    3. The 'ZP domain' module of human ZP1 has functional activity and may have a role during fertilization in humans. PMID: 20831819
    4. ZP1 binds to capacitated spermatozoa and induces acrosomal exocytosis. PMID: 20504872
    5. ZP proteins were detected in both the oocyte and the granulosa cells as early as the primordial follicle stage in the human. The detection of ZP proteins in the quiescent primordial follicle suggests that these proteins have been present since oogenesis. PMID: 18033806

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  • 相关疾病：
    Oocyte maturation defect 1 (OOMD1)
  • 亚细胞定位：
    [Processed zona pellucida sperm-binding protein 1]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ZP domain family, ZPB subfamily
  • 组织特异性：
    Expressed in oocytes (at protein level).
  • 数据库链接：

    HGNC: 13187

    OMIM: 195000

    KEGG: hsa:22917

    STRING: 9606.ENSP00000278853

    UniGene: Hs.172130