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ZIC1 Antibody

  • 货号：
    CSB-PA795975
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from Jurkat cells and COLO cells, using ZIC1/2/3 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using ZIC1/2/3 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZIC1 Polyclonal antibody
  • Uniprot No.：
    Q15915
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human ZIC1/2/3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
  • 基因功能参考文献：
    1. Study demonstrate that ZIC1 plays a tumor suppressive role in breast cancer, by targeting surviving, significantly downregulating its expression. PMID: 29956756
    2. Two proposed mechanisms for Zic-mediated cerebellar developmental control have been documented: regulation of neuronal progenitor proliferation-differentiation and the patterning of the cerebellar primordium. Clinical studies have also revealed that ZIC1 gain of function mutations contribute to coronal craniosynostosis, a rare skull malformation. PMID: 29442326
    3. By unbiased genome-wide DNA methylation profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR, SST, and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer PMID: 28119363
    4. down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor PMID: 26670443
    5. our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis PMID: 26207911
    6. Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability. PMID: 26340333
    7. ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. PMID: 25953442
    8. aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC). PMID: 24782033
    9. ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K/Akt and MAPK signaling pathways and transcription factor FOXO3a. PMID: 24684457
    10. Loss of ZIC1 expression is associated with malignant pleural mesothelioma. PMID: 24457242
    11. Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome PMID: 23774800
    12. Zic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling PMID: 23937294
    13. Overexpression of ZIC1 results in inactivation of Shh, PI(3)K and MAPK signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer. PMID: 22799764
    14. ZIC1 may potentially function as a tumor suppressor gene PMID: 21347233
    15. The down-regulated expression of ZIC1 and KLOTHO in colorectal carcinoma may relate to promoter methylation. PMID: 21671493
    16. Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion. PMID: 21204220
    17. ZIC1, ZIC2, and ZIC5 may have roles in meningiomas PMID: 20199689
    18. ZIC1 contributes to the pathogenesis of liposarcoma. ZIC1 knockdown inhibits proliferation, reduces invasion, and induces apoptosis in dedifferentiated and myxoid/round cell liposarcoma cell lines. PMID: 20713527
    19. zic-1-mediated transcription is repressed by the intracellular domain of teneurin-2 PMID: 12783990
    20. ZIC1 was excluded from playing a causal role in most cases of JS (Joubert syndrome) as no disease-associated mutations were identified. PMID: 14981711
    21. Through physical mapping of 3q2 interstitial deletions in several individuals with Dandy-Walker malformation (DWM), we defined the first critical region associated with DWM, encompassing two adjacent Zinc finger in cerebellum genes, ZIC1 and ZIC4. PMID: 15338008
    22. this is the first report describing ZIC1 expression in mesenchymal proliferations and a role for DNA methylation in the control of ZIC1 expression. PMID: 17936758
    23. Study investigated the effect of an evolutionarily conserved GQ from the mRNA of the zinc-finger protein of the cerebellum 1 (Zic-1); the motif was found to drastically repress translation without affecting the mRNA level in vivo. PMID: 18515550
    24. These results revealed ZIC1 as a novel candidate tumor suppressor gene downregulated through promoter hypermethylation in gastric cancer. PMID: 19135984

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  • 相关疾病：
    Craniosynostosis 6 (CRS6)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    GLI C2H2-type zinc-finger protein family
  • 组织特异性：
    CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medullobla
  • 数据库链接：

    HGNC: 12872

    OMIM: 600470

    KEGG: hsa:7545

    STRING: 9606.ENSP00000282928

    UniGene: Hs.598590