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  4. ZHX1 Antibody

ZHX1 Antibody

  • 中文名称：
    ZHX1兔多克隆抗体
  • 货号：
    CSB-PA026481GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UKY1
  • 基因名：
    ZHX1
  • 别名：
    ZHX 1 antibody; ZHX1 antibody; ZHX1_HUMAN antibody; Zinc finger and homeodomain protein 1 antibody; Zinc fingers and homeobox 1 antibody; Zinc fingers and homeoboxes 1 antibody; Zinc fingers and homeoboxes protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ZHX1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.
  • 基因功能参考文献：
    1. ZHX1 expression is correlated with renal cell carcinoma progression and poor survival. PMID: 28152006
    2. ZHX1 was found to play essential roles in the proliferation, migration, and invasion of cholangiocarcinoma cells, and its effect on the proliferation was mediated partially through EGR1. PMID: 27835650
    3. together, this study demonstrates that ZHX1 plays crucial roles in the progression of glioblastoma, and its findings suggest that ZHX1 be viewed as a potential prognostic maker and therapeutic target of glioblastoma. PMID: 28351300
    4. miR-199a-3p may function as a novel tumor promoter in gastric cancer and its oncogenic activity may involve the direct targeting and inhibition of ZHX1 PMID: 25448600
    5. Low expression of ZHX1 may be responsible for hepatocarcinogenesis. PMID: 24064680
    6. Study showed that ZHX1 is SUMOylated by Ubc9 with SUMO1 at the sites K159, K454, and K626 and that the SUMOylation of ZHX1 regulated the stability, ubiquitination and transcriptional activity of ZHX1. PMID: 23686912
    7. This study characterized features of ZHX-1 involved in nuclear localization, dimerization, and transcriptional activity, and mapped these domains. PMID: 12237128
    8. a search of ZHX1-interacting proteins using a yeast two-hybrid system PMID: 12659632
    9. ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease PMID: 17056598
    10. ZHX1 enhanced the transcriptional repression mediated by DNMT3B when DNMT3B is directly targeted to DNA. These results showed for the first the direct linkage between DNMT and zinc-fingers homeoboxes protein, leading to enhanced gene silencing by DNMT3B PMID: 17303076
    11. structure of the tandem zinc-finger region of human ZHX1 PMID: 19348505

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  • 亚细胞定位：
    Nucleus. Note=Colocalized in the nucleus with DNMT3B.
  • 蛋白家族：
    ZHX family
  • 组织特异性：
    Ubiquitously expressed. Expressed in podocytes.
  • 数据库链接：

    HGNC: 12871

    OMIM: 604764

    KEGG: hsa:11244

    STRING: 9606.ENSP00000297857

    UniGene: Hs.521800