ZFP36L2 Antibody
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货号:CSB-PA988387
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规格:¥1100
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图片:
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其他:
产品详情
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Uniprot No.:P47974
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基因名:
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别名:BRF2 antibody; Butyrate response factor 2 antibody; C3H1 type-like 2 antibody; EGF response factor 2 antibody; EGF-response factor 2 antibody; ERF 2 antibody; ERF-2 antibody; ERF2 antibody; Protein TIS11D antibody; RNF162C antibody; TIS11D antibody; TISD_HUMAN antibody; ZFP36 like 2 antibody; ZFP36 ring finger protein like 2 antibody; ZFP36-like 2 antibody; Zfp36l2 antibody; Zinc finger protein 36 antibody; Zinc finger protein 36, C3H type like 1 antibody; zinc finger protein 36, C3H type like 2 antibody; Zinc finger protein 36, C3H1 type like 2 antibody; Zinc finger protein, C3H type, 36 like 2 antibody
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宿主:Rabbit
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反应种属:Human,Mouse
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免疫原:Synthetic peptide of Human ZFP36L2
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation...显示更多
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基因功能参考文献:
- Significantly mutated gene ZFP36L2 displayed strong antiproliferation function in Esophageal Squamous Cell Carcinoma but not in Esophageal Adenocarcinomas. PMID: 28860350
- silencing ZFP36L2 inhibited cancer cell aggressiveness in pancreatic ductal adenocarcinoma cell lines, and overexpression of ZFP36L2 was confirmed in pancreatic ductal adenocarcinoma clinical specimens PMID: 27862697
- Study of the role of the C-terminal residues in the structure of unbound TIS11d, the E220A mutant and the truncation mutant lacking the last two residues (D219/E220) using molecular dynamics, NMR spectroscopy, and biochemical methods PMID: 25809263
- Data suggest that the dysregulation of TIS11D function is associated with the pathogenesis of certain types of leukemia. PMID: 21109922
- ZFP36L2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
- Multiple nanosecond timescale molecular dynamics trajectories of TIS11d wild-type and E157R/E195K mutant with different RNA sequences were performed to investigate the molecular basis for RNA binding specificities of this TZF domain. PMID: 20506496
- Sequence specificity in RNA recognition is achieved by a network of intermolecular hydrogen bonds, mostly between TIS11d main-chain functional groups and the Watson-Crick edges of the bases PMID: 14981510
- These data suggest TIS11D as a candidate p53 target gene that may be part of the network of genes responsible for p53-dependent apoptosis. PMID: 17172869
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相关疾病:Defects in ZFP36L2 may be a cause of leukemias. Frameshfits mutations disrupting ZFP36L2 have been found in a patient with acute myeloid leukemia (PubMed:21109922).
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亚细胞定位:Nucleus. Cytoplasm.
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组织特异性:Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers. Expressed in epidermal keratinocytes (at protein level).
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数据库链接:
HGNC: 1108
OMIM: 612053
KEGG: hsa:678
STRING: 9606.ENSP00000282388
UniGene: Hs.503093