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ZBTB48 Antibody

  • 货号：
    CSB-PA026340DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ZBTB48 antibody at 0.31µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: K562 whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Lane 4: U251 whole cell lysate
      Lane 5: Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 77 kDa
      Observed band size: 77 kDa
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA026340DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA026340DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZBTB48 Polyclonal antibody
  • Uniprot No.：
    P10074
  • 基因名：
    ZBTB48
  • 别名：
    0610011D15Rik antibody; AI327031 antibody; GLI Kruppel family member HKR3 antibody; HKR3 antibody; Krueppel related zinc finger protein 3 antibody; Krueppel-related zinc finger protein 3 antibody; OTTMUSP00000031803 antibody; pp9964 antibody; Protein HKR3 antibody; RP23-445E20.3 antibody; ZBT48_HUMAN antibody; ZBTB 48 antibody; Zbtb48 antibody; Zinc finger and BTB domain containing 48 antibody; Zinc finger and BTB domain containing protein 48 antibody; Zinc finger and BTB domain-containing protein 48 antibody; Zinc finger protein 855 antibody; ZNF855 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Telomere zinc finger-associated protein (1-280AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.
  • 基因功能参考文献：
    1. study demonstrate through a combination of RNAseq, ChIPseq and expression proteomics experiments that ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1). This discovery places ZBTB48 at the interface of telomere length regulation, transcriptional control and mitochondrial metabolism PMID: 28500257
    2. this study describes a specific telomere-associated protein: TZAP (telomeric zinc finger-associated protein). Binding of TZAP to long telomeres represents the switch that triggers telomere trimming, setting the upper limit of telomere length. PMID: 28082411
    3. HKR3 potently activated the transcription of the tumor suppressor gene ARF by acting on the proximal promoter region (bp, -149 approximately +53), which contains Sp1 and FBI-1 binding elements (FREs). PMID: 24382891
  • 亚细胞定位：
    Nucleus. Chromosome, telomere.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Detected in adrenal gland and neuroblastoma.
  • 数据库链接：

    HGNC: 4930

    OMIM: 165270

    KEGG: hsa:3104

    STRING: 9606.ENSP00000366902

    UniGene: Hs.502330