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ZBED3 Antibody

  • 货号：
    CSB-PA839344LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA839344LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZBED3 Polyclonal antibody
  • Uniprot No.：
    Q96IU2
  • 基因名：
    ZBED3
  • 别名：
    MGC15435 antibody; ZBED3 antibody; ZBED3_HUMAN antibody; Zinc finger BED domain containing 3 antibody; Zinc finger BED domain-containing protein 3 antibody; Zinc finger BED type containing 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger BED domain-containing protein 3 protein (1-234AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ZBED3 Antibody (CSB-PA839344LA01HU)，的标记方式是Non-conjugated。对于ZBED3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839344LB01HU ZBED3 Antibody, HRP conjugated ELISA
    FITC CSB-PA839344LC01HU ZBED3 Antibody, FITC conjugated
    Biotin CSB-PA839344LD01HU ZBED3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression. Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network. Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation.
  • 基因功能参考文献：
    1. Zbed3 concentrations were significantly higher in metabolic syndrome patients compared with healthy subjects. Circulating Zbed3 concentrations were associated with glucose and lipid parameters, markers of adiposity, and blood pressure. PMID: 28346859
    2. Finally, the wnt-inhibitor DKK1 could reverse the stimulatory effect of ZBED3-AS1 on chondrogenesis. These findings demonstrate the role of a new lncRNA, ZBED3-AS1, in SFMSC chondrogenesis and may improve osteoarthritis treatment. PMID: 28431932
    3. results suggest that Zbed3 may contribute to lung cancer cell invasion through regulating beta-catenin and p120ctn-1 and may be a promissing cancer marker in non-small cell lung cancer PMID: 25263389
    4. results suggest that the Zbed3 protein may be a cytokine associated with insulin resistance in humans that is influenced by glucose and insulin levels. PMID: 24283382
    5. Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation. PMID: 19141611

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  • 亚细胞定位：
    Cytoplasm. Membrane. Secreted.
  • 组织特异性：
    Secreted in blood plasma, and expressed in skeletal muscle and adipose tissue (at protein level).
  • 数据库链接：

    HGNC: 20711

    OMIM: 615250

    KEGG: hsa:84327

    UniGene: Hs.584988