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YKT6 Antibody

  • 货号：
    CSB-PA026265LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: YKT6 antibody at 12µg/ml + A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 23, 19 kDa
      Observed band size: 23 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA026265LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The production process of the YKT6 polyclonal antibody typically involves injecting the rabbit with the recombinant human synaptobrevin homolog YKT6 protein (10-195aa), collecting its serum, and isolating and purifying the antibody through protein G affinity chromatography.

    The YKT6 polyclonal antibody is only reactive with the YKT6 protein from human samples. This antibody contains few impurities, claiming up to 95% purity. It has been tested in ELISA, WB, and IHC. It is commonly used as a tool to detect, quantify, and localize the YKT6 protein in various tissues and cell types.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) YKT6 Polyclonal antibody
  • Uniprot No.：
    O15498
  • 基因名：
    YKT6
  • 别名：
    R SNARE antibody; SNARE protein Ykt6 antibody; Synaptobrevin homolog YKT6 antibody; YKT 6 antibody; YKT6 antibody; YKT6 S. cerevisiae homolog of antibody; YKT6 v SNARE homolog antibody; YKT6 v SNARE protein antibody; YKT6_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Synaptobrevin homolog YKT6 protein (10-195AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，YKT6 Antibody (CSB-PA026265LA01HU)，的标记方式是Non-conjugated。对于YKT6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA026265LB01HU YKT6 Antibody, HRP conjugated ELISA
    FITC CSB-PA026265LC01HU YKT6 Antibody, FITC conjugated
    Biotin CSB-PA026265LD01HU YKT6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
  • 基因功能参考文献：
    1. YKT6 is a key molecule in the regulation of exosome release in lung cancer cells and is in turn precisely regulated by miR-134 and miR-135b. Moreover, YKT6 levels impact prognosis of resected Non small cell lung cancer patients. PMID: 27285987
    2. abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders PMID: 11884350
    3. Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport. PMID: 12388752
    4. N-ethylmaleimide-sensitive factor-dependent SNARE-priming complex disassembly is required for efficient exocytosis from mast cells. PMID: 14607937
    5. mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel. PMID: 16821082

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.
  • 蛋白家族：
    Synaptobrevin family
  • 数据库链接：

    HGNC: 16959

    OMIM: 606209

    KEGG: hsa:10652

    STRING: 9606.ENSP00000223369

    UniGene: Hs.520794