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XPNPEP3 Antibody

  • 中文名称：
    XPNPEP3兔多克隆抗体
  • 货号：
    CSB-PA026220GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NQH7
  • 基因名：
    XPNPEP3
  • 别名：
    Aminopeptidase P3 antibody; APP3 antibody; NPHPL1 antibody; OTTHUMP00000199806 antibody; Probable Xaa Pro aminopeptidase 3 antibody; Probable Xaa-Pro aminopeptidase 3 antibody; X Pro aminopeptidase 3 antibody; X prolyl aminopeptidase (aminopeptidase P) 3 antibody; X-Pro aminopeptidase 3 antibody; XPNPEP3 antibody; XPP3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human XPNPEP3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position.; Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
  • 基因功能参考文献：
    1. results therefore suggest XPNPEP3 to be a transcriptional target of Wnt/beta-catenin pathway with particular significance for CRC PMID: 29383790
    2. Data suggest that human XPNPEP3, Ashbya gossypii Icp55, and Fusarium graminearum Icp55 exhibit structural and functional properties of genuine Xaa-Pro specific aminopeptidases; these enzymes appear to function in the previously observed mitochondrial role of Icp55 in processing of Nfs1 (mitochondrial cysteine desulfurase) substrate. [Icp55 = intermediate-cleavage metalloexopeptidases 55] PMID: 28476889
    3. The findings reveal that APP3m is a new member of the TNF-TNFR2 signaling complex and characterize an APP3-mediated TNFR2 signal transduction mechanism that induces activation of JNK1 and JNK2. PMID: 25609706
    4. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. PMID: 20179356
  • 相关疾病：
    Nephronophthisis-like nephropathy 1 (NPHPL1)
  • 亚细胞定位：
    [Isoform 1]: Mitochondrion. Cytoplasm.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Peptidase M24B family
  • 组织特异性：
    Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
  • 数据库链接：

    HGNC: 28052

    OMIM: 613159

    KEGG: hsa:63929

    STRING: 9606.ENSP00000349658

    UniGene: Hs.529163