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XAB2 Antibody

  • 货号：
    CSB-PA862073LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, A549 whole cell lysate
      All lanes: XAB2 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 101 kDa
      Observed band size: 101 kDa
    • IHC image of CSB-PA862073LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA862073LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of PC-3 cells with CSB-PA862073LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) XAB2 Polyclonal antibody
  • Uniprot No.：
    Q9HCS7
  • 基因名：
    XAB2
  • 别名：
    0610041O14Rik antibody; adapter protein ATH 55 antibody; Adapter protein ATH-55 antibody; Ath55 antibody; AV025587 antibody; Crn related protein kim1 antibody; crn-related protein kim1 antibody; DKFZp762C1015 antibody; HCNP antibody; HCNP protein antibody; HCRN antibody; KIAA1177 antibody; NTC90 antibody; PP3898 antibody; Pre-mRNA-splicing factor SYF1 antibody; Protein HCNP antibody; RNA splicing factor antibody; SYF1 antibody; SYF1 homolog antibody; SYF1 homolog, RNA splicing factor antibody; SYF1 pre mRNA splicing factor antibody; SYF1_HUMAN antibody; Xab2 antibody; XPA binding protein 2 antibody; XPA-binding protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pre-mRNA-splicing factor SYF1 protein (750-840AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，XAB2 Antibody (CSB-PA862073LA01HU)，的标记方式是Non-conjugated。对于XAB2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA862073LB01HU XAB2 Antibody, HRP conjugated ELISA
    FITC CSB-PA862073LC01HU XAB2 Antibody, FITC conjugated
    Biotin CSB-PA862073LD01HU XAB2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
  • 基因功能参考文献：
    1. these results support a novel function of XAB2 in mitotic cell cycle regulation, which is partially mediated by transcription regulation on CENPE. PMID: 27735937
    2. we suggest that the XAB2 complex mediates DNA damage response events important for the end resection step of homologous recombination , and speculate that its adjacent-localization relative to double-strand break marked by gH2AX is important for this function PMID: 27084940
    3. Study identifies XAB2 tagSNPs (rs794078 and rs4134816) significantly associated with the risk of non-small cell lung cancer (NSCLC) in Chinese population, which supports XAB2 playing significant role in the development of NSCLC. PMID: 26228655
    4. Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair and XAB2 expression. PMID: 25027282
    5. XAB2 complex is a multifunctional factor involved in pre-mRNA splicing, transcription, and transcription-coupled DNA repair. PMID: 17981804

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Crooked-neck family
  • 数据库链接：

    HGNC: 14089

    OMIM: 610850

    KEGG: hsa:56949

    STRING: 9606.ENSP00000351137

    UniGene: Hs.9822