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WRB Antibody

  • 货号：
    CSB-PA026148LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse spleen tissue
      All lanes: WRB antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 20, 17 kDa
      Observed band size: 20 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA026148LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA026148LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA026148LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) WRB Polyclonal antibody
  • Uniprot No.：
    O00258
  • 基因名：
    WRB
  • 别名：
    GET1; CHD5; WRB; Guided entry of tail-anchored proteins factor 1; Congenital heart disease 5 protein; Tail-anchored protein insertion receptor WRB; Tryptophan-rich basic protein
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Tail-anchored protein insertion receptor WRB protein (38-99AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，WRB Antibody (CSB-PA026148LA01HU)，的标记方式是Non-conjugated。对于WRB Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA026148LB01HU WRB Antibody, HRP conjugated ELISA
    FITC CSB-PA026148LC01HU WRB Antibody, FITC conjugated
    Biotin CSB-PA026148LD01HU WRB Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG.
  • 基因功能参考文献：
    1. WRB gene contains a maternally imprinted differentially methylated region (DMR). The maternally inherited 5mCpG imprints at the WRB DMR are uncoupled from the parental allele expression of WRB and ten neighboring genes in twelve biosamples (brain, blood, fallopian tube, fetal large and small intestine, hESCs, large airway epithelial cells, thyroid, muscle, epidermal keratinocytes, ovary, skin, and testis). PMID: 27100087
    2. Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells. PMID: 23041287
    3. The coiled-coil domain of WRB is the binding site for TRC40/Asna1. PMID: 21444755
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    WRB/GET1 family
  • 数据库链接：

    HGNC: 12790

    OMIM: 602915

    KEGG: hsa:7485

    STRING: 9606.ENSP00000327716

    UniGene: Hs.198308