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WIPF1 Antibody

  • 货号：
    CSB-PA060082
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O43516
  • 基因名：
  • 别名：
    WIPF1 antibody; WASPIP antibody; WIP antibody; WAS/WASL-interacting protein family member 1 antibody; Protein PRPL-2 antibody; Wiskott-Aldrich syndrome protein-interacting protein antibody; WASP-interacting protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human WIP.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles. Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
  • 基因功能参考文献：
    1. WIP deficiency should be considered as a cause for autosomal-recessive immunodeficiency PMID: 27742395
    2. the present study identifies the WIPF1 gene as having novel oncogenic functions and playing an important role in the invasiveness and aggressiveness of thyroid cancer when aberrantly up-regulated by the BRAF V600E/MAPK pathway through its promoter demethylation. PMID: 27863429
    3. WIP controls tumor growth by boosting signals that stabilize the YAP/TAZ complex via a mechanism mediated by the endocytic/endosomal system. PMID: 27851961
    4. Results suggest that local invasiveness of ameloblastoma is dependent upon the migratory potential of its tumour cells as defined by their distribution of cortactin, N-WASP and WIP in correlation with F-actin cytoskeletal dynamics. PMID: 26752341
    5. establish a new cancer stem cell signalling pathway downstream of mtp53 in which AKT2 regulates WIP and controls YAP/TAZ stability. PMID: 28166194
    6. Knocking down WIP expression in A549 cells significantly reduced RhoA levels and WIP was found to interact with RhoA suggesting that WIP might be executing its function by regulating RhoA. PMID: 27939884
    7. Study provides evidence that WIP and WIRE contribute to breast cancer cell invasiveness through coordinated roles. WIP seems necessary for the assembly of invasive protrusions, whereas WIRE regulates their maturation, which leads to matrix degradation. PMID: 27009365
    8. WIP was shown to interact with various binding partners, including the signaling proteins Nck, CrkL and cortactin. PMID: 22837718
    9. These findings reveal WIP as a previously unreported regulator of neuronal maturation and synaptic activity PMID: 21810783
    10. These findings indicate that WIP deficiency should be suspected in patients with features of WAS in whom WAS sequence and mRNA levels are normal. PMID: 22231303
    11. show that the N-WASP EVH1 domain specifically binds a 25 residue motif from the WASP Interacting Protein (WIP) PMID: 12437929
    12. Only in the presence of WASP-interacting protein (WIP) can human WASP suppress the growth defect of Saccharomyces cerevisiae las17Delta strain. PMID: 16488394
    13. A 1.3 mD multiprotein complex consisting of WASp-interacting protein (WIP), Wiskott-Aldrich syndrome protein (WASp), actin, and myosin IIA formigg during NK cell activation was identified with a role in complex formation and NK cell activity regulation. PMID: 16606694
    14. WASP-interacting protein stabilizes Wiskott-Aldrich syndrome protein(WASP) and suggest that it may also be important for its function PMID: 17213309
    15. In this review, in addition to its WASP-independent functions, the role of WIP is to regulate the activity and stability of WASP and shuttle WASP to areas of actin assembly. PMID: 17949983
    16. WIP is involved in lytic granule transport and is essential for regulation of Natural killer cell cytotoxic function PMID: 18258743
    17. Groups of colorectal cancer, breast cancer, and glioma patients with low expression of the WIPF1 co-expression module generally had a favorable prognosis. PMID: 19399471

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  • 相关疾病：
    Wiskott-Aldrich syndrome 2 (WAS2)
  • 亚细胞定位：
    Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle.
  • 蛋白家族：
    Verprolin family
  • 组织特异性：
    Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.
  • 数据库链接：

    HGNC: 12736

    OMIM: 602357

    KEGG: hsa:7456

    STRING: 9606.ENSP00000352802

    UniGene: Hs.128067