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WFIKKN1 Antibody

  • 货号：
    CSB-PA842729OA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA842729OA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) WFIKKN1 Polyclonal antibody
  • Uniprot No.：
    Q96NZ8
  • 基因名：
    WFIKKN1
  • 别名：
    WFIKKN1 antibody; C16orf12 antibody; GASP2 antibody; WFIKKN antibody; PSEC0040 antibody; WAP antibody; Kazal antibody; immunoglobulin antibody; Kunitz and NTR domain-containing protein 1 antibody; Growth and differentiation factor-associated serum protein 2 antibody; GASP-2 antibody; hGASP-2 antibody; WAP antibody; follistatin antibody; immunoglobulin antibody; Kunitz and NTR domain-containing protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 protein (187-207AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，WFIKKN1 Antibody (CSB-PA842729OA01HU)，的标记方式是Non-conjugated。对于WFIKKN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA842729OB01HU WFIKKN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA842729OC01HU WFIKKN1 Antibody, FITC conjugated
    Biotin CSB-PA842729OD01HU WFIKKN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity.
  • 基因功能参考文献：
    1. In this review, we summarize current knowledge about the WFIKKN proteins and propose that they are "companion" proteins for various growth factors by providing localized and sustained presentation of TGFB proteins to their respective receptors, thus regulating the balance between the activation of Smad and non-Smad pathways by TGFB. PMID: 27325460
    2. Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity. PMID: 27782377
    3. Data suggest that myostatin binding to its receptor (activin receptors type II) can be blocked by WFIKKN1 but not WFIKKN2; various forms of myostatin (promyostatin, myostatin pro-domain, and latent/processed myostatin) bind WFIKKN1 but not WFIKKN2. PMID: 23829672
    4. data indicate that WFIKKN proteins are antagonists of GDF8 and GDF11, but in the case of TGFbeta1, BMP2 and BMP4 they function as growth factor binding proteins PMID: 21054789
    5. Newly discovered WFIKKNPR gene structure and tissue distribution of gene expression is commpared with that of the WFIKKN gene in adult and fetal tissues and organs. PMID: 11928817
    6. Data suggest that the physiological target of WFIKKN protein may be trypsin. PMID: 12709070
    7. three-dimensional structure of a Kunitz domain with a tryptophan residue at the P02 site of the protease-recognition loop PMID: 16791741
    8. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. PMID: 18596030

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    WFIKKN family
  • 组织特异性：
    Expressed in pancreas, kidney, liver, placenta, and lung.
  • 数据库链接：

    HGNC: 30912

    OMIM: 608021

    KEGG: hsa:117166

    STRING: 9606.ENSP00000324763

    UniGene: Hs.345818