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WDHD1 Antibody

  • 货号：
    CSB-PA004488
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using WDHD1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O75717
  • 基因名：
    WDHD1
  • 别名：
    WDHD1 antibody; AND1 antibody; WD repeat and HMG-box DNA-binding protein 1 antibody; Acidic nucleoplasmic DNA-binding protein 1 antibody; And-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human WDHD1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.
  • 基因功能参考文献：
    1. And-1 interacts with CtIP and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair. PMID: 27940552
    2. important role of And-1 in homologous recombination repair by regulating CtIP-mediated DNA double-strand break end resection PMID: 27940557
    3. findings provide important insights into the mechanistic details of human AND-1 function, advancing our understanding of replisome formation during eukaryotic replication. PMID: 28381552
    4. The WDHD1 gene, one of the genes that is upregulated in human papillomavirus E7-expressing cells, was found to play an important role in E7-induced G1 checkpoint abrogation and rereplication PMID: 27099318
    5. Results provide additional evidence suggesting that WDHD1 is involved in the mismatch repair pathway. PMID: 27037360
    6. RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells. PMID: 25602958
    7. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. PMID: 26082189
    8. The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex. PMID: 24255107
    9. And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres. PMID: 23184928
    10. Human And-1 facilitates loading of the MCM2-7 helicase onto chromatin during the assembly of prereplicative complex. PMID: 23093411
    11. Data show that And-1 forms a complex with both histone H3 and Gcn5. PMID: 21725360
    12. in human cells, hCtf4 plays an essential role in DNA replication and its ability to stimulate the replicative DNA polymerases may contribute to this effect PMID: 20089864
    13. Mcm10 is required for chromatin loading of And-1. PMID: 17761813
    14. AND-1 coordinates multiple cellular events in S phase and G2 phase. PMID: 19439411
    15. Assembly of the Cdc45-Mcm2-7-GINS complex requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. PMID: 19805216

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  • 亚细胞定位：
    Nucleus, nucleoplasm.
  • 数据库链接：

    HGNC: 23170

    OMIM: 608126

    KEGG: hsa:11169

    STRING: 9606.ENSP00000353793

    UniGene: Hs.385998