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WDFY4 Antibody

  • 货号：
    CSB-PA747798LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA747798LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA747798LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The WDFY4 polyclonal antibody is raised in rabbits against the peptide corresponding to amino acid residues 1-322 of the human WDFY4 protein. It occurs as an unconjugated IgG. It is purified by protein G and reaches up to 95% in purity. And it only reacts with human WDFY4 protein. Validations of this antibody have been done in ELISA and IHC assays. The target protein WDFY4 is required for the cross-presentation of cell- and bacterial-associated antigens. It also plays a key role in cDC1-mediated viral and tumor immunity.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) WDFY4 Polyclonal antibody
  • Uniprot No.：
    Q6ZS81
  • 基因名：
    WDFY4
  • 别名：
    WDFY4 antibody; C10orf64 antibody; KIAA1607WD repeat- and FYVE domain-containing protein 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human WD repeat- and FYVE domain-containing protein 4 protein (1-322AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，WDFY4 Antibody (CSB-PA747798LA01HU)，的标记方式是Non-conjugated。对于WDFY4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA747798LB01HU WDFY4 Antibody, HRP conjugated ELISA
    FITC CSB-PA747798LC01HU WDFY4 Antibody, FITC conjugated
    Biotin CSB-PA747798LD01HU WDFY4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Plays also a role in B-cell survival through regulation of autophagy.
  • 基因功能参考文献：
    1. A significantly increased risk for RA associated with the WDFY4 rs7097397 AG genotype. PMID: 24549174
    2. rs877819 SNP in WDFY4 may be associated with systemic lupus erythematosus by reduced binding of YY1 and downregulating WDFY4 expression. PMID: 22972472
    3. Genetic variants in ETS1 and WDFY4 were found to be associated with systemic lupus erythematosus, in the Asian population studied. PMID: 20169177
  • 亚细胞定位：
    Early endosome. Endoplasmic reticulum.
  • 数据库链接：

    HGNC: 29323

    OMIM: 613316

    KEGG: hsa:57705

    STRING: 9606.ENSP00000320563

    UniGene: Hs.287379