Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. VPS36 Antibody

VPS36 Antibody

  • 货号：
    CSB-PA801240OA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA801240OA01HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VPS36 Polyclonal antibody
  • Uniprot No.：
    Q86VN1
  • 基因名：
  • 别名：
    C13orf9 antibody; CGI 145 antibody; EAP45 antibody; ELL associated protein of 45 kDa antibody; ELL-associated protein of 45 kDa antibody; ESCRT-II complex subunit VPS36 antibody; Vacuolar protein sorting associated protein 36 antibody; Vacuolar protein-sorting-associated protein 36 antibody; Vps36 antibody; VPS36_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Vacuolar protein-sorting-associated protein 36 protein (87-105AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，VPS36 Antibody (CSB-PA801240OA01HU)，的标记方式是Non-conjugated。对于VPS36 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA801240OB01HU VPS36 Antibody, HRP conjugated ELISA
    FITC CSB-PA801240OC01HU VPS36 Antibody, FITC conjugated
    Biotin CSB-PA801240OD01HU VPS36 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
  • 基因功能参考文献：
    1. RAB27A, RAB27B and VPS36 are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B and VPS36, with RAB27A and RAB27B being dependent on VPS36. PMID: 28197629
    2. Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. PMID: 17057716
  • 亚细胞定位：
    Cytoplasm. Endosome. Late endosome. Membrane. Nucleus.
  • 蛋白家族：
    VPS36 family
  • 数据库链接：

    HGNC: 20312

    OMIM: 610903

    KEGG: hsa:51028

    STRING: 9606.ENSP00000367299

    UniGene: Hs.109520