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VP2 Antibody

  • 中文名称：
    VP2兔多克隆抗体
  • 货号：
    CSB-PA302471LA01CID
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: VP2 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 62 kDa
      Observed band size: 62 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) VP2 Polyclonal antibody
  • Uniprot No.：
    P69484
  • 基因名：
    VP2
  • 别名：
    VP2Dual specificity protein phosphatase VP2 antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Chicken anemia virus
  • 免疫原：
    Recombinant Chicken anemia virus Dual specificity protein phosphatase VP2 protein (1-216AA)
  • 免疫原种属：
    Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
  • 标记方式：
    Non-conjugated

    本页面中的产品，VP2 Antibody (CSB-PA302471LA01CID)，的标记方式是Non-conjugated。对于VP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA302471LB01CID VP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA302471LC01CID VP2 Antibody, FITC conjugated
    Biotin CSB-PA302471LD01CID VP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.
  • 基因功能参考文献：
    1. The deletion of the C-terminal region of apoptin also impaired the replication of chicken anemia virus and attenuated its virulence in chickens. PMID: 28222746
    2. this study reports the use of apoptin and poly (I:C) combination as a novel strategy for cancer immunotherapy PMID: 27064544
    3. VP3-induced apoptosis, caspase-dependent intrinsic pathway plays an important role with the cleavage of poly (ADP-ribose) polymerase (PARP) PMID: 25809990
    4. Results show that The apoptosis induced by human adenovirus serotype 5 (AdHu5)-apoptin was independent of anti-apoptotic Bcl-2 and Bcl-xL proteins and the p53 pathway. PMID: 23812727
    5. In silico three-dimensional modeling of apoptin, molecular docking experiments between apoptin model and the known structure of Bcr-Abl, and the 3D structures of SH2 domains of CrkL and Bcr-Abl, were performed. PMID: 22253690
    6. These data demonstrate that Hsc70 is responsible for the down-regulation of Apoptin induced RelA/p65 gene expression. PMID: 21707973
    7. Apoptin induced the translocation of endogenous Hsc70 from the cytoplasm to the nucleus, and both were co-localized in the nucleus. PMID: 21565169
    8. Apoptin, expressed from the pseudotype baculovirus vector, has the potential to become a therapeutic agent for the treatment of solid tumors PMID: 19824041
    9. Apoptin, a protein from chicken anemia virus without an apparent cellular homologue, can induce apoptosis in mammalian cells. Its cytotoxicity is limited to transformed or tumor cells. PMID: 14765135
    10. Apoptin induces chromatin condensation when it is expressed in the nucleus and in the cytoplasm. PMID: 15965608
    11. role of c-Jun N-terminal kinase (JNK) in the apoptosis induced by apoptin gene in human lymphoma cell U937 PMID: 15989809
    12. Apoptin expression caused an increase in the tumor suppressor lipid ceramide, which regulates the cellular stress response PMID: 16887394
    13. apoptin kills tumor cells independently of PML and sumoylation, however, the interaction of apoptin with PML and small ubiquitin-like modifier (SUMO) proteins might be relevant for chicken anemia virus replication PMID: 16924230
    14. suggest that apoptin modulates ceramide/sphingolipid metabolism as part of its mechanism of action PMID: 16926120
    15. apoptin had an anti-neoplastic effect in vivo and in vitro in RSV-induced tumours PMID: 16963752
    16. T108 phosphorylation may only be required for the apoptotic activity mediated through the C-terminal apoptosis domain. PMID: 17223075
    17. PI3-K/Akt pathways have a dual role in both survival and cell death processes depending on the stimulus. PMID: 18021174
    18. Human peptidyl-prolyl isomerase-like 3 (Ppil3) is one of the Apoptin-associated proteins. PMID: 18474220
    19. C-terminus of apoptin (residues 74-121) is sufficient for tumor cell-enhanced nuclear targeting through phosphoinhibition of apoptin (74-121)-mediated nuclear export occurring exclusively in tumor cells. PMID: 18798550
    20. apoptin is necessary not only for DNA replication but also virus-like particle production of chicken anemia virus PMID: 19091368
    21. the pathway of apoptin-induced apoptosis and show that it essentially depends on abnormal phosphatidylinositol 3-kinase (PI3-kinase)/Akt activation, resulting in the activation of the cyclin-dependent kinase CDK2 PMID: 19103742
    22. Apoptin specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Review. PMID: 19374922

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  • 蛋白家族：
    Gyrovirus protein VP2 family