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VOPP1 Antibody

  • 货号：
    CSB-PA03545A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: VOPP1 antibody at 2µg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 20, 19, 18 kDa
      Observed band size: 50, 70, 80 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA03545A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VOPP1 Polyclonal antibody
  • Uniprot No.：
    Q96AW1
  • 基因名：
    VOPP1
  • 别名：
    VOPP1 antibody; ECOP antibody; GASP antibody; Vesicular antibody; overexpressed in cancer antibody; prosurvival protein 1 antibody; EGFR-coamplified and overexpressed protein antibody; ECop antibody; Glioblastoma-amplified secreted protein antibody; Putative NF-kappa-B-activating protein 055N antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Vesicular, overexpressed in cancer, prosurvival protein 1 protein (23-172AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，VOPP1 Antibody (CSB-PA03545A0Rb)，的标记方式是Non-conjugated。对于VOPP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA03545B0Rb VOPP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA03545C0Rb VOPP1 Antibody, FITC conjugated
    Biotin CSB-PA03545D0Rb VOPP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
  • 基因功能参考文献：
    1. miR-218 inhibits human lung adenocarcinoma cell migration and invasion via the suppression of Ecop and Robo1 expression PMID: 28936884
    2. Candidate gene eQTL showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene, previously linked to altered BB response, and high expression of VOPP1. PMID: 26860460
    3. VOPP1 is overexpressed in gastric adenocarcinoma, which is involved in promoting cell proliferation and migration and thus might serve as a putative oncogene. PMID: 25398664
    4. Upregulation of ECOP is associated with glioma. PMID: 23243056
    5. overexpression in cancer participates in the control of the intracellular redox state; its loss leads to oxidative cellular injury leading to cell death by the intrinsic apoptotic pathway PMID: 21519330
    6. ECOP was used as a molecular marker in patients with chronic wounds to guide surgical debridement. PMID: 17515955
    7. Results identify ECOP as a protein relevant to the biology of SCC. PMID: 19525979

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  • 亚细胞定位：
    Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.
  • 蛋白家族：
    VOPP1/ECOP family
  • 组织特异性：
    Widely expressed with highest levels in thymus and ovary.
  • 数据库链接：

    HGNC: 34518

    OMIM: 611915

    KEGG: hsa:81552

    STRING: 9606.ENSP00000285279

    UniGene: Hs.488307