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VENTX Antibody

  • 货号：
    CSB-PA528513DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA528513DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA528513DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VENTX Polyclonal antibody
  • Uniprot No.：
    O95231
  • 基因名：
    VENTX
  • 别名：
    hemopoietic progenitor homeobox protein VENTX2 antibody; Homeobox protein VENTX antibody; HPX42B antibody; MGC119910 antibody; MGC119911 antibody; NA88A antibody; VENT homeobox homolog antibody; VENT like homeobox 2 antibody; VENT like homeobox protein 2 antibody; VENT-like homeobox protein 2 antibody; VENTX antibody; VENTX_HUMAN antibody; VENTX2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein VENTX protein (1-258AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in ventralization.
  • 基因功能参考文献：
    1. Findings suggest potential applications of homeobox protein VentX (VentX)-regulated tumor-associated macrophages (TAMs) in cancer immunotherapy. PMID: 29872044
    2. VENTX impairs expression of genes involved in erythroid differentiation and is highly expressed in patients with acute erythroid leukemia. PMID: 27888632
    3. VentX induces apoptosis of cancer cells in a p53-independent manner PMID: 27175592
    4. Data suggest that homeobox transcription factor VentX may be a target to modulate Dendritic cells (DCs) functions and manage inflammatory diseases. PMID: 24706756
    5. VentX regulates critical cell cycle regulators and Wnt downstream genes previously implicated in HSC/MPP proliferation and expansion. PMID: 22791709
    6. Results provide mechanistic insight into the crucial roles of VentX in macrophage differentiation and proinflammatory activation and suggest that dysregulation of VentX may play a role in the pathogenesis of autoimmune diseases. PMID: 21670496
    7. Data show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways. PMID: 21325273
    8. these data extend our insights into the function of embryonic mesodermal factors in human postnatal hematopoiesis and indicate a role for VENTX in normal and malignant myelopoiesis. PMID: 20833819
    9. a potential role of VentX in the clinical behavior of hematopoietic malignancies. PMID: 20028861

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.
  • 数据库链接：

    HGNC: 13639

    OMIM: 607158

    KEGG: hsa:27287

    STRING: 9606.ENSP00000357556

    UniGene: Hs.125231