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VCPIP1 Antibody

  • 货号：
    CSB-PA025814GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96JH7
  • 基因名：
    VCPIP1
  • 别名：
    Deubiquitinating protein VCIP135 antibody; DUBA3 antibody; KIAA1850 antibody; Valosin containing protein (p97)/p47 complex interacting protein 1 antibody; Valosin containing protein p97/p47 complex interacting protein 1 antibody; Valosin containing protein p97/p47 complex interacting protein p135 antibody; Valosin-containing protein p97/p47 complex-interacting protein 1 antibody; Valosin-containing protein p97/p47 complex-interacting protein p135 antibody; VCIP1_HUMAN antibody; VCIP135 antibody; VCP/p47 complex-interacting 135-kDa protein antibody; Vcpip1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human VCPIP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.; (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients.
  • 基因功能参考文献：
    1. BoNT/A catalytic light chain binds to, and is a substrate for, the ubiquitin ligase HECTD2. However, the light chain evades proteasomal degradation by the dominant effect of a deubiquitinating enzyme, VCIP135/VCPIP1. This deubiquitinating enzyme binds BoNT/A light chain directly. PMID: 28584101
    2. Phosphorylation and ubiquitination are coordinated via VCIP135 to control Golgi membrane dynamics in the cell cycle. PMID: 25904330
    3. VCIP135 phosphorylation regulates its Golgi membrane association and p97 interaction, and thus contributes to the tight control of the Golgi disassembly and reassembly process during the cell cycle. PMID: 24163436
    4. the phosphorylation of VCIP135 on Threonine-760 and Serine-767 inhibits p97-mediated Golgi membrane fusion at mitosis PMID: 23500464
    5. evidence of tyrosine phosphorylation during sperm capacitation PMID: 12509440

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Endoplasmic reticulum. Golgi apparatus, Golgi stack.
  • 数据库链接：

    HGNC: 30897

    OMIM: 611745

    KEGG: hsa:80124

    STRING: 9606.ENSP00000309031

    UniGene: Hs.632066