Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. VASN Antibody

VASN Antibody

  • 货号：
    CSB-PA025796OA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, SH-SY5Y whole cell lysate, K562 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, HL60 whole cell lysate
      All lanes: VASN antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 72 kDa
      Observed band size: 72 kDa
    • IHC image of CSB-PA025796OA01HU diluted at 1:640 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of MCF-7 cells with CSB-PA025796OA01HU at 1:213, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品描述：

    The product CSB-PA025796OA01HU is an IgG rabbit polyclonal VASN antibody suitable for the recognition of human VASN by ELISA, WB, IHC, and IF. The recombinant human Vasorin protein (553-572aa) is used to immunize the rabbit to generate the VASN polyclonal antibody. VASN antibody is available as the non-conjugated IgG antibody form. Its purity is over 95% using protein G purification.

    VASN mainly acts as a regulator of cell signaling and extracellular matrix (ECM) formation in various tissues throughout the body. It is involved in the regulation of various cellular processes, including cell proliferation, differentiation, and migration. VASN has been involved in the pathogenesis of various vascular diseases such as atherosclerosis and hypertension, as well as neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VASN Polyclonal antibody
  • Uniprot No.：
    Q6EMK4
  • 基因名：
    VASN
  • 别名：
    2610528G05Rik antibody; PRO1282 antibody; PRO357 antibody; Protein slit-like 2 antibody; Slit like 2 antibody; Slitl2 antibody; UNQ314 antibody; Vasn antibody; VASN_HUMAN antibody; Vasorin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Vasorin protein (553-572AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，VASN Antibody (CSB-PA025796OA01HU)，的标记方式是Non-conjugated。对于VASN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA025796OB01HU VASN Antibody, HRP conjugated ELISA
    FITC CSB-PA025796OC01HU VASN Antibody, FITC conjugated
    Biotin CSB-PA025796OD01HU VASN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:500-1:1000
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as an inhibitor of TGF-beta signaling.
  • 基因功能参考文献：
    1. confirmed for the first time that HepG2-derived VASN can be transferred to human umbilical vein endothelial cells (HUVECs) via receptor mediated endocytosis of exosomes, at least in part through HSPGs PMID: 26157350
    2. results suggest that down-regulation of vasorin expression contributes to neointimal formation after vascular injury and that vasorin modulates cellular responses to pathological stimuli in the vessel wall [vasorin] PMID: 15247411
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Secreted.
  • 组织特异性：
    Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending ao
  • 数据库链接：

    HGNC: 18517

    OMIM: 608843

    KEGG: hsa:114990

    STRING: 9606.ENSP00000306864

    UniGene: Hs.372579