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VANGL1 Antibody

  • 货号：
    CSB-PA848385ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: VANGL1 antibody at 3.38µg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 60 kDa
      Observed band size: 60 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA848385ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA848385ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VANGL1 Polyclonal antibody
  • Uniprot No.：
    Q8TAA9
  • 基因名：
  • 别名：
    VANGL1; STB2; Vang-like protein 1; Loop-tail protein 2 homolog; LPP2; Strabismus 2; Van Gogh-like protein 1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Vang-like protein 1 protein (275-524AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. High KITENIN expression is associated with cholangiocarcinoma. PMID: 29366806
    2. VANGL1 gene is not associated with Adolescent Idiopathic Scoliosis in the Chinese population PMID: 29189642
    3. two rare missense mutations in VANGL1, encoding a receptor involved in WNT/PCP signaling, may be associated with Adolescent Idiopathic Scoliosis PMID: 27755493
    4. Study provides evidence that KITENIN functions in the maintenance of a higher expression level of ErbB4 in advanced colorectal cancer tissues, independent of ubiquitin-mediated degradation via Nrdp1. PMID: 27648936
    5. We first propose the use of a DNA biosensor to detect the missense single nucleotide polymorphism (rs4839469 c.346G>A p.Ala116Thr) of the vangl1 gene PMID: 26914375
    6. a novel and ultrasensitive sandwich-type immunosensor was fabricated to detect Vangl in human serum using C60-templated AuPt as labels and rGO-TEPA-PTC-NH2 as the platform. PMID: 26735870
    7. Results found that KITENIN is associated with tumor progression by enhancing angiogenesis in colorectal cancer. PMID: 26496979
    8. s silenced VANGL1 gene expression in the HepG2 HCC cell line by stable transfection with a vector containing siRNA template for VANGL1 and investigated the change in cell invasion and motility. PMID: 25874746
    9. High levels of KITENIN increased glioma invasiveness and progression, and are associated with the up-regulation of EMT and stemness markers. PMID: 25605251
    10. The rs4839469 allele of VANGL1 was obviously associated with neural tube defects (NTDs). And genotype GC increased the risk of NTDs, changes in the three-dimensional protein structure may have impacted its biological functions. PMID: 24407469
    11. VANGL1 mutations are associated with neural tube defects. PMID: 25208524
    12. Elevated KITENIN expression is associated with drug resistance in colorectal cancer. PMID: 24893630
    13. Findings identify that KITENIN-targeting miR-124, miR-27a, and miR-30b function as endogenous inhibitors of colorectal cancer cell motility and demonstrate that miR-124 plays a suppressor role in colorectal tumorigenesis. PMID: 24909917
    14. The results show that the Vangl1 amino terminus lacks PM targeting determinants, and these are restricted to the carboxy terminus, including the predicted PDZBM motif at the C-terminus PMID: 24452931
    15. KITENIN is associated with tumor invasiveness and metastasis in human oral cavity squamous cell carcinoma. PMID: 22840317
    16. NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells PMID: 22179838
    17. KITENIN is associated with human colorectal cancer progression including invasion and metastasis. PMID: 21418393
    18. a compact membrane-associated portion with very short predicted extra- and intracellular loops, while the protein harbors a large intracellular domain PMID: 21291170
    19. This study demonstrates a high degree of functional conservation of VANGL genes across evolution and provides a model system for studying potential variants identified in human neural tube defects. PMID: 20043994
    20. KITENIN plays an important role in human gastric cancer progression by AP-1 activation. PMID: 20944126
    21. Molecular cloning and characterization of Strabismus 2 PMID: 11956595
    22. VANGL protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. PMID: 16410243
    23. In a protein-protein interaction assay V239I abolished interaction of VANGL1 protein with its binding partners, disheveled-1, -2, and -3. These findings implicate VANGL1 as a risk factor in human neural-tube defects. PMID: 17409324
    24. VANGL1 increases invasion and migration of mouse squamous cancer cells and promotes pulmonary metastasis in a mouse squamous tumor model. PMID: 19166844
    25. role of VANGL1 as a risk factor in the development of spinal neural tube defects PMID: 19319979

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  • 相关疾病：
    Neural tube defects (NTD); Sacral defect with anterior meningocele (SDAM)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Vang family
  • 组织特异性：
    According to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary.
  • 数据库链接：

    HGNC: 15512

    OMIM: 182940

    KEGG: hsa:81839

    STRING: 9606.ENSP00000310800

    UniGene: Hs.515130