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  4. USP47 Antibody

USP47 Antibody

  • 货号：
    CSB-PA459673
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA459673(USP47 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA459673(USP47 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A172 cell, Primary antibody: CSB-PA459673(USP47 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q96K76
  • 基因名：
    USP47
  • 别名：
    Deubiquitinating enzyme 47 antibody; TFRP antibody; Trf TATA binding protein related factor proximal homolog antibody; Trf TATA binding protein related factor proximal homolog Drosophila antibody; Ubiquitin carboxyl-terminal hydrolase 47 antibody; Ubiquitin specific peptidase 47 antibody; Ubiquitin specific processing protease 47 antibody; Ubiquitin specific protease 47 antibody; Ubiquitin thioesterase 47 antibody; Ubiquitin thiolesterase 47 antibody; Ubiquitin-specific-processing protease 47 antibody; UBP47_HUMAN antibody; USP47 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human USP47
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
  • 基因功能参考文献：
    1. these results suggest that USP47 may play distinct roles in ubiquitin-mediated cellular processes via de-ubiquitinating enzymes activity. PMID: 26115687
    2. miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A. PMID: 25429829
    3. USP47 is a deubiquitinase that prevents beta-catenin ubiquitination. PMID: 26169834
    4. Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47. PMID: 25253721
    5. The results of this study indicated that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. PMID: 23904609
    6. USP47 has a role in regulating DNA repair and maintaining genome integrity PMID: 21362556
    7. USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies. PMID: 19966869

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 组织特异性：
    Expressed in skeletal muscle, heart and testis.
  • 数据库链接：

    HGNC: 20076

    OMIM: 614460

    KEGG: hsa:55031

    STRING: 9606.ENSP00000339957

    UniGene: Hs.577256