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USP37 Antibody

  • 货号：
    CSB-PA025728GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q86T82
  • 基因名：
    USP37
  • 别名：
    Deubiquitinating enzyme 3 antibody; Deubiquitinating enzyme 37 antibody; EC 3.1.2.15 antibody; KIAA1594 antibody; MGC117261 antibody; OTTHUMP00000164146 antibody; tmp_locus_50 antibody; Ubiquitin carboxyl-terminal hydrolase 37 antibody; Ubiquitin specific peptidase 37 antibody; Ubiquitin specific processing protease 37 antibody; Ubiquitin specific protease 37 antibody; Ubiquitin thioesterase 37 antibody; Ubiquitin thiolesterase 37 antibody; Ubiquitin-specific-processing protease 37 antibody; UBP37_HUMAN antibody; USP37 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human USP37
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
  • 基因功能参考文献：
    1. these findings reveal a role for REST-associated G9a and histone H3K9 methylation in the repression of USP37 expression in medulloblastoma. Reactivation of USP37 by G9a inhibition has the potential for therapeutic applications in REST-expressing medulloblastomas PMID: 28483947
    2. USP37 interacts with Cdt1 and is able to de-ubiquitinate Cdt1 in vivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin. PMID: 27296872
    3. USP37 associates with cohesin and contributes to sister chromatid resolution. Cohesion defects are rescued by expression of an RNAi-resistant USP37, but not the catalytically impaired USP37(C350A) mutant. PMID: 26299517
    4. USP37 is significantly upregulated in human lung cancer tissues, where its expression is positively correlated with c-Myc protein expression. PMID: 25284584
    5. These results suggested that the UIMs in USP37 contribute to the full enzymatic activity, but not ubiquitin chain substrate specificity, of USP37 possibly by holding the ubiquitin chain substrate in the proximity of the catalytic core. PMID: 24324262
    6. our findings of USP37-modulating PLZF/RARA stability and cell transformation suggest that USP37 is a potential therapeutic target for PLZF/RARA-associated APL PMID: 23208507
    7. USP37 links REST to the control of p27 stability and cell proliferation. PMID: 22665064
    8. Skp1-Cul1-F-box ubiquitin ligase (SCF(betaTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry PMID: 23027877
    9. The deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A. USP37 was induced by E2F factors in G1, peaked at G1/S, and was degraded in late mitosis. Phosphorylation of USP37 by CDK2 stimulated its full activity. PMID: 21596315

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  • 蛋白家族：
    Peptidase C19 family
  • 组织特异性：
    Expressed in brain and prostate.
  • 数据库链接：

    HGNC: 20063

    KEGG: hsa:57695

    STRING: 9606.ENSP00000258399

    UniGene: Hs.166068