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USP3 Antibody

  • 货号：
    CSB-PA025720GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6I4
  • 基因名：
  • 别名：
    Deubiquitinating enzyme 3 antibody; EC 3.1.2.15 antibody; SIH003 antibody; Ubiquitin carboxyl-terminal hydrolase 3 antibody; Ubiquitin specific peptidase 3 antibody; Ubiquitin specific processing protease 3 antibody; Ubiquitin Specific Protease 3 antibody; Ubiquitin thioesterase 3 antibody; Ubiquitin thiolesterase 3 antibody; Ubiquitin-specific-processing protease 3 antibody; UBP antibody; UBP3_HUMAN antibody; Usp3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human USP3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
  • 基因功能参考文献：
    1. Data found that USP3 was overexpressed in gastric cancer (GC) tissues and cells. USP3 overexpression can be a useful biomarker for predicting the outcomes of GC patients. Moreover, USP3 was shown to influence cell proliferation by regulating cell cycle control and metastasis-related proteins. In vivo experiments showed that USP3 promoted GC tumor growth and metastasis. PMID: 30168892
    2. Depletion of USP3 lead to accelerated degradation of p53 in normal cells thereby enhanced cell proliferation and transformation. Reconstitution of wildtype USP3, but not the USP3 C168S mutant, restored the stability of p53 protein and inhibited cell proliferation and transformation. PMID: 28807825
    3. Taken together, the results suggested that USP3 is a negative regulator of ubiquitination signaling, counteracting RNF168- and RNF8-mediated ubiquitination. PMID: 24196443
    4. the role of UCP3 gene in functional status and survival at old age. PMID: 22743239
    5. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20445134
    6. Ubiquitin-specific protease 3 (USP3) is a deubiquitinating enzyme for monoubiquitinated histones H2A and H2B; USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo. PMID: 17980597

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  • 亚细胞定位：
    Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
  • 蛋白家族：
    Peptidase C19 family, USP3 subfamily
  • 组织特异性：
    Expressed in all tissues examined, with strongest expression in pancreas.
  • 数据库链接：

    HGNC: 12626

    OMIM: 604728

    KEGG: hsa:9960

    STRING: 9606.ENSP00000369681

    UniGene: Hs.458499