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USP16 Antibody

  • 货号：
    CSB-PA006653
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using USP16 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y5T5
  • 基因名：
  • 别名：
    Deubiquitinating enzyme 16 antibody; Human ubiquitin processing protease antibody; MSTP039 antibody; Ubiquitin carboxyl-terminal hydrolase 16 antibody; Ubiquitin Specific peptidase 16 antibody; Ubiquitin Specific Protease 16 antibody; Ubiquitin thiolesterase 16 antibody; Ubiquitin-processing protease UBP-M antibody; Ubiquitin-specific-processing protease 16 antibody; UBP M antibody; UBP16_HUMAN antibody; UBPM antibody; usp16 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human USP16.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
  • 基因功能参考文献：
    1. USP16 was frequently downregulated. PMID: 27633997
    2. USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome. PMID: 27586445
    3. The data unveil a unique mechanism by which Usp16 promotes the localization and maintenance of Plk1 on the kinetochores for proper chromosome alignment. PMID: 26323689
    4. Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal. PMID: 25305019
    5. S552P disrupts the interaction between Ubp-M and nuclear export protein CRM1, increasing Ubp-M nuclear retention as cells progress into M phase, revealing a critical function for Ubp-M S552P. PMID: 24013421
    6. in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and postnatal neural progenitors, whereas downregulation of USP16 partially rescues the proliferation defects of Down's syndrome fibroblasts PMID: 24025767
    7. Study reports the solution structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ubiquitin; the Ubp-M BUZ domain features three zinc-binding sites consisting of 12 residues. PMID: 17512543
    8. knockdown of Ubp-M in HeLa cells results in slow cell growth rates owing to defects in the mitotic phase of the cell cycle PMID: 17914355
    9. a new cryptic USP16-RUNX1 fusion in chronic myelomonocytic leukemia PMID: 18925961

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  • 相关疾病：
    A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Peptidase C19 family, USP16 subfamily
  • 组织特异性：
    Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 12614

    OMIM: 604735

    KEGG: hsa:10600

    STRING: 9606.ENSP00000334808

    UniGene: Hs.99819