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USP12 Antibody

  • 货号：
    CSB-PA025699GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O75317
  • 基因名：
    USP12
  • 别名：
    Deubiquitinating enzyme 12 antibody; OTTHUMP00000042337 antibody; UBH 1 antibody; UBH1 antibody; Ubiquitin carboxyl terminal hydrolase 12 antibody; Ubiquitin carboxyl-terminal hydrolase 12 antibody; Ubiquitin hydrolyzing enzyme 1 antibody; Ubiquitin specific peptidase 12 antibody; Ubiquitin specific processing protease 12 antibody; Ubiquitin specific protease 12 like 1 antibody; Ubiquitin thioesterase 12 antibody; Ubiquitin thiolesterase 12 antibody; Ubiquitin-hydrolyzing enzyme 1 antibody; Ubiquitin-specific-processing protease 12 antibody; UBP12_HUMAN antibody; USP 12 antibody; Usp12 antibody; USP12L1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human USP12
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.
  • 基因功能参考文献：
    1. Usp12 deubiquitylates and prevents lysosomal degradation of LAT and Trat1 to maintain the proximal TCR complex for the duration of signaling. PMID: 26811477
    2. Usp12 directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt. PMID: 25216524
    3. our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival PMID: 24145035
    4. Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. PMID: 24056413
    5. The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. PMID: 22778262

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  • 蛋白家族：
    Peptidase C19 family, USP12/USP46 subfamily
  • 数据库链接：

    HGNC: 20485

    OMIM: 603091

    KEGG: hsa:219333

    STRING: 9606.ENSP00000282344

    UniGene: Hs.42400