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USO1 Antibody

  • 货号：
    CSB-PA003610
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using p115 Polyclonal Antibody
    • Western Blot analysis of K562 293 cells using p115 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O60763
  • 基因名：
    USO1
  • 别名：
    General vesicular transport factor antibody; General vesicular transport factor p115 antibody; P115 antibody; Protein USO1 homolog antibody; TAP antibody; Transcytosis associated protein antibody; Transcytosis-associated protein antibody; Uso1 antibody; USO1_HUMAN antibody; VDP antibody; Vesicle docking protein antibody; Vesicle docking protein p115 antibody; Vesicle-docking protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human p115.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
  • 基因功能参考文献：
    1. USO1 gene may be a promising target for the therapy of human multiple myeloma and its diagnosis marker. PMID: 26898451
    2. USO1 gene has a critical role in human colon cancer: USO1 is involved in cell proliferation and cell migration of colon cancer cells. PMID: 26184508
    3. P115 promotes proliferation of gastric cancer cells through an interaction with MIF. PMID: 24379579
    4. Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology. PMID: 20209057
    5. p115 plays a critical role in mitosis progression, implicating it as the only known golgin to regulate both mitosis and apoptosis PMID: 21536679
    6. a conserved tethering function of the Golgi protein p115 CTF which promotes p53-ERK interaction for the amplification of the apoptotic signal. PMID: 21147777
    7. Data show that the number of tandem ARM repeats in an ARM fold ranges from 6 to 12. PMID: 20126549
    8. Data show that p115 degradation plays a key role in amplifying the apoptotic response independently of Golgi fragmentation. PMID: 12438416
    9. p115 acts directly, rather than via a tether, to catalyze trans-SNARE complex formation preceding membrane fusion. PMID: 14736916
    10. The results suggest that p115 is involved in vesicular transport between endoplasmic reticulum and the Golgi, along with microtubule networks. PMID: 16256943
    11. The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively. PMID: 17274799
    12. Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat PMID: 18434597
    13. nuclear import of the p115 CTF is required for it to stimulate the apoptotic response and suggest that its mode of action is confined to the nucleus. PMID: 19028683
    14. terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering PMID: 19247479
    15. p115 is a critical intermediary component in the regulated secretion of MIF from monocytes/macrophages PMID: 19454686

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  • 亚细胞定位：
    Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族：
    VDP/USO1/EDE1 family
  • 数据库链接：

    HGNC: 30904

    OMIM: 603344

    KEGG: hsa:8615

    UniGene: Hs.744877