Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. UGP2 Antibody

UGP2 Antibody

  • 货号：
    CSB-PA100573
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA100573(UGP2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell, Primary antibody: CSB-PA100573(UGP2 Antibody) at dilution 1/500 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q16851
  • 基因名：
    UGP2
  • 别名：
    pHC379 antibody; UDP glucose diphosphorylase antibody; UDP glucose pyrophosphorylase 1 antibody; UDP glucose pyrophosphorylase 2 antibody; UDP glucose pyrophosphorylase antibody; UDP-glucose pyrophosphorylase antibody; UDPG antibody; UDPGP 2 antibody; UDPGP antibody; UDPGP2 antibody; UGP 1 antibody; UGP 2 antibody; UGP1 antibody; Ugp2 antibody; UGPA_HUMAN antibody; UGPase 2 antibody; UGPase antibody; UGPP 1 antibody; UGPP 2 antibody; UGPP1 antibody; UGPP2 antibody; Uridyl diphosphate glucose pyrophosphorylase 1 antibody; Uridyl diphosphate glucose pyrophosphorylase 2 antibody; UTP glucose 1 phosphate uridyltransferase antibody; UTP glucose 1 phosphate uridylyltransferase 2 antibody; UTP glucose 1 phosphate uridylyltransferase antibody; UTP--glucose-1-phosphate uridylyltransferase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human UGP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
  • 基因功能参考文献：
    1. High UGP2 expression is associated with malignant pancreatic lesions. PMID: 29347944
    2. This study provides clear evidence that the octameric state is a prerequisite for activity in the uridine diphosphate-glucose pyrophosphorylase. PMID: 23254995
    3. The crystal structure was determined and shown to form octamers through end-to-end and side-by-side interactions. Mutagenesis studies showed that both dissociation of octamers and mutations of the latch loop can significantly affect the activity. PMID: 22132858
    4. GYS1 regulation by HIF plays a central role in the hypoxic accumulation of glycogen, and hypoxia also upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1) PMID: 20300197
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    UDPGP type 1 family
  • 组织特异性：
    Highly expressed in various brain regions. Expressed in amygdala, anterior cingulate cortex, caudate, cerebellar hemisphere, cerebellum, cortex, frontal cortex, hippocampus, hypothalamus, nucleus accumbens, putamen, spinal cord and substantia nigra. Also
  • 数据库链接：

    HGNC: 12527

    OMIM: 191750

    KEGG: hsa:7360

    STRING: 9606.ENSP00000338703

    UniGene: Hs.516217