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UBXN6 Antibody

  • 货号：
    CSB-PA874859LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: UBXN6 antibody at 1.2μg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 50, 44 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA874859LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA874859LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UBXN6 Polyclonal antibody
  • Uniprot No.：
    Q9BZV1
  • 基因名：
  • 别名：
    UBX domain containing 1 antibody; UBX domain containing 2 antibody; UBX domain containing protein 1 antibody; UBX domain containing protein 6 antibody; UBX domain protein 6 antibody; UBX domain-containing protein 1 antibody; UBX domain-containing protein 6 antibody; UBXD1 antibody; UBXDC2 antibody; Ubxn6 antibody; UBXN6_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human UBX domain-containing protein 6 protein (1-388AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UBXN6 Antibody (CSB-PA874859LA01HU)，的标记方式是Non-conjugated。对于UBXN6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA874859LB01HU UBXN6 Antibody, HRP conjugated ELISA
    FITC CSB-PA874859LC01HU UBXN6 Antibody, FITC conjugated
    Biotin CSB-PA874859LD01HU UBXN6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
  • 基因功能参考文献：
    1. These results indicate that the outer membrane protein MCL1 is degraded by the VCP-UBXD1 complex and that the process is promoted by the presence of mutant Huntingtin. PMID: 27913212
    2. UBXD1-N intercalates into the p97-ND1 interface, thereby modulating interdomain communication of p97 domains and its activity with relevance for disease pathogenesis PMID: 26475856
    3. Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1. PMID: 23335559
    4. UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53. PMID: 22337587
    5. Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells. PMID: 21822278
    6. UBXD1 is a novel co-factor of the human p97 ATPase. PMID: 18656546
    7. An additional p97 binding site in UBXD1 that competed with the p47 cofactor for binding to the N domain of p97 was identified. PMID: 19174149
    8. these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP. PMID: 19275885

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
  • 组织特异性：
    Enhanced expression in testis.
  • 数据库链接：

    HGNC: 14928

    OMIM: 611946

    KEGG: hsa:80700

    STRING: 9606.ENSP00000301281

    UniGene: Hs.435255