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UBE2W Antibody

  • 货号：
    CSB-PA025485GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96B02
  • 基因名：
  • 别名：
    FLJ11011 antibody; hUBC 16 antibody; hUBC16 antibody; Probable ubiquitin conjugating enzyme E2 W antibody; Probable ubiquitin-conjugating enzyme E2 W antibody; UBC 16 antibody; UBC-16 antibody; UBC16 antibody; UBE 2W antibody; ube2w antibody; UBE2W_HUMAN antibody; Ubiquitin carrier protein W antibody; Ubiquitin conjugating enzyme 16 antibody; Ubiquitin conjugating enzyme E2 W antibody; Ubiquitin conjugating enzyme E2W antibody; Ubiquitin protein ligase W antibody; Ubiquitin-protein ligase W antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UBE2W
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate.
  • 基因功能参考文献：
    1. Thus, although Rnf4 and Ube2w functionally interact in vitro, these genetic experiments indicate that in response to DNA damage Ube2w and Rnf4 function in distinct pathways. PMID: 27185577
    2. TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. PMID: 26101372
    3. We show the ubequitin-conjugating enzyme (E2) Ube2w uses a unique mechanism to facilitate the specific ubiquitination of the alpha-amino group PMID: 25436519
    4. Ube2w has novel enzymatic properties that direct ubiquitination of the N terminus of substrates PMID: 23696636
    5. UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6. PMID: 21229326
    6. human Ubiquitin-conjugating enzyme (E2) is homologous to the Arabidopsis thaliana UBC-16 gene product and contains 2 nuclear localization signals PMID: 16368532

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 组织特异性：
    Widely expressed, with highest expression in brain, liver, pancreas and heart.
  • 数据库链接：

    HGNC: 25616

    OMIM: 614277

    KEGG: hsa:55284

    STRING: 9606.ENSP00000454445

    UniGene: Hs.128841