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UBASH3B Antibody

  • 货号：
    CSB-PA840585ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA840585ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA840585ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UBASH3B Polyclonal antibody
  • Uniprot No.：
    Q8TF42
  • 基因名：
    UBASH3B
  • 别名：
    Cbl interacting protein p70 antibody; Cbl interacting protein Sts 1 antibody; Cbl interacting protein Sts1 antibody; Cbl-interacting protein p70 antibody; KIAA1959 antibody; MGC15437 antibody; Nm23 phosphorylated unknown substrate antibody; p70 antibody; SH3 domain containing 70 kDa protein antibody; Sts 1 antibody; STS-1 antibody; STS1 antibody; Suppressor of T cell receptor signaling 1 antibody; Suppressor of T-cell receptor signaling 1 antibody; T-cell ubiquitin ligand 2 antibody; TULA-2 antibody; Tyrosine-protein phosphatase STS1/TULA2 antibody; Ubash3b antibody; Ubiquitin associated and SH3 domain containing B antibody; Ubiquitin-associated and SH3 domain-containing protein B antibody; UBS3B_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin-associated and SH3 domain-containing protein B protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
  • 基因功能参考文献：
    1. Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70. PMID: 24256567
    2. The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation. PMID: 28690151
    3. The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention. PMID: 26449661
    4. targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells PMID: 26766443
    5. These results show that TULA-2 is a target of miR-148a-3p PMID: 26516227
    6. This recovery involves the phosphorylation of p70 independent of mTOR. PMID: 25271148
    7. results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells PMID: 25959715
    8. UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity. PMID: 23784775
    9. Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses. PMID: 20585042
    10. hsp70 inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia-blast crisis and acute myeloid leukemia cells. PMID: 15388581

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 数据库链接：

    HGNC: 29884

    OMIM: 609201

    KEGG: hsa:84959

    STRING: 9606.ENSP00000284273

    UniGene: Hs.444075