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UBAP2L Antibody

  • 货号：
    CSB-PA285591
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA285591(UBAP2L Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA285591(UBAP2L Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q14157
  • 基因名：
  • 别名：
    FLJ42300 antibody; KIAA0144 antibody; NICE 4 antibody; NICE4 antibody; Protein NICE-4 antibody; Protein NICE4 antibody; Ubap2l antibody; Ubiquitin associated protein 2 like antibody; Ubiquitin-associated protein 2-like antibody; UBP2L_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human UBAP2L
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). Required for efficient formation of stress granules.
  • 基因功能参考文献：
    1. UBAP2L plays an oncogenic role in HCC, and knockdown of its expression significantly inhibits HCC growth and metastasis, which may be related to the regulation of PI3K/AKT and P53 signaling pathways by UBAP2L. PMID: 30291221
    2. High UBAP2L expression is associated with breast cancer. PMID: 29196913
    3. UBAP2L was overexpressed in HCC, and patients with high UBAP2L expression had unfavorable prognosis. PMID: 28981479
    4. UBAP2L is amplified in 15% of human primary lung adenocarcinoma specimens. Such patients express higher levels of UBAP2L and show a reduction in survival when compared with those who do not have this gene amplification. PMID: 28754713
    5. UBAP2L plays a critical role in maintenance of the metastatic ability of Hepatocellular Carcinoma Cells cells via SNAIL1 Regulation and is predictive of a poor clinical outcome. PMID: 28334716
    6. These results suggest that UBAP2L has a key role in glioma cell growth, and may act as an oncogene to promote malignant glioma development. PMID: 26310274
    7. arginine residues in the RGG/RG motif of UBAP2L were directly methylated by PRMT1. RGG/RG motif of UBAP2L is essential for the proper alignment of chromosomes. PMID: 26381755
    8. Knockdown of UBAP2L in prostate carcinoma inhibited cell proliferation, migration, and colony formation ability, and blocked cell cycle progression. PMID: 25069639
    9. Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L. PMID: 25185265

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  • 亚细胞定位：
    Cytoplasm, Stress granule.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 29877

    OMIM: 616472

    KEGG: hsa:9898

    STRING: 9606.ENSP00000355343

    UniGene: Hs.490551