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UBA3 Antibody

  • 货号：
    CSB-PA851532ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA851532ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UBA3 Polyclonal antibody
  • Uniprot No.：
    Q8TBC4
  • 基因名：
  • 别名：
    DKFZp566J164 antibody; EC 6.3.2. antibody; hUba3 antibody; MGC22384 antibody; NEDD8 activating enzyme E1 catalytic subunit antibody; NEDD8 activating enzyme E1C antibody; Nedd8 activating enzyme hUba3 antibody; NEDD8-activating enzyme E1 catalytic subunit antibody; NEDD8-activating enzyme E1C antibody; uba3 antibody; UBA3 ubiquitin activating enzyme E1 homolog antibody; UBA3_HUMAN antibody; UBE1C antibody; Ubiquitin activating enzyme 3 antibody; Ubiquitin activating enzyme E1C antibody; Ubiquitin-activating enzyme 3 antibody; Ubiquitin-activating enzyme E1C antibody; Ubiquitin-like modifier-activating enzyme 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human NEDD8-activating enzyme E1 catalytic subunit protein (234-463AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
  • 基因功能参考文献：
    1. The study demonstrated that two mutations in UBA3 which were not previously reported confer MLN4924 resistance to MLN4924, a selective NEDD8-activating enzyme inhibitor. PMID: 24691136
    2. Report role for neddylation via Nedd8-activating enzyme in the regulation of tumor angiogenesis. PMID: 24525735
    3. Demonstrated that Uba3-betaGD is an independently folded domain in solution and that residues involved in E2 binding are absent from the NMR spectrum, indicating that the E2-binding surface on Uba3-betaGD interconverts between multiple conformations. PMID: 22821745
    4. crystal structure of a complex between the C-terminal domain from NEDD8's heterodimeric E1 (APPBP1-UBA3) and the catalytic core domain of NEDD8's E2 (Ubc12) PMID: 15694336
    5. X-ray crystallographic analysis of APPBP1-UBA3-NEDD8 shows that APPBP1-UBA3's preference for NEDD8's Ala72 appears to be indirect, due to proper positioning of UBA3's Arg190. PMID: 18652489

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  • 蛋白家族：
    Ubiquitin-activating E1 family, UBA3 subfamily
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 12470

    OMIM: 603172

    KEGG: hsa:9039

    STRING: 9606.ENSP00000354340

    UniGene: Hs.154320