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TXNDC5 Antibody

  • 货号：
    CSB-PA847679ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TXNDC5 antibody at 4.9μg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Colo320 whole cell lysate
      Lane 3: Mouse stomach tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 48, 37 kDa
      Observed band size: 48 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA847679ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA847679ESR1HU at dilution of 1:100
    • Immunoprecipitating TXNDC5 in HepG2 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA847679ESR1HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA847679ESR1HU (8μg) + HepG2 whole cell lysate (500μg)
      Lane 3: HepG2 whole cell lysate (10μg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TXNDC5 Polyclonal antibody
  • Uniprot No.：
    Q8NBS9
  • 基因名：
  • 别名：
    EndoPDI antibody; Endoplasmic reticulum protein ERp46 antibody; Endoplasmic reticulum resident protein 46 antibody; Endothelial protein disulphide isomerase antibody; ER protein 46 antibody; ERp46 antibody; Hcc 2 antibody; MGC3178 antibody; PDIA15 antibody; Protein disulfide isomerase family A member 15 antibody; STRF8 antibody; Thioredoxin domain containing 5 (endoplasmic reticulum) antibody; Thioredoxin domain containing 5 antibody; Thioredoxin domain containing protein 5 antibody; Thioredoxin domain-containing protein 5 antibody; Thioredoxin like protein p46 antibody; Thioredoxin related protein antibody; Thioredoxin-like protein p46 antibody; TLP46 antibody; TXND5_HUMAN antibody; TXNDC 5 antibody; Txndc5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Thioredoxin domain-containing protein 5 protein (1-324AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.
  • 基因功能参考文献：
    1. Hypoxia induces the expression of TXNDC5 via upregulating HIF-1alpha in colorectal cancer cells. PMID: 29749460
    2. TXNDC5 is also closely associated with rheumatoid arthritis, diabetes, hepatic steatosis and vitiligo. [review] PMID: 28604976
    3. High TXNDC5 expression is associated with renal cell carcinoma. PMID: 26810069
    4. we defined an important role of TXNDC5 in CRPC and further investigations are needed to screen TXNDC5 antagonists as a novel therapeutic approaches to treat PCa patients with Castration-resistant prostate cancer. PMID: 25500540
    5. Role of ERp46 in oxidative protein folding.Independent actions of ERp46 thioredoxin domains on folding substrates.Structure of thioredoxin ERp46 domains. PMID: 24462249
    6. suggest that the tumorigenic properties of ERp46 in RCC cells are not related to an inhibitory modulation of AdipoR1 PMID: 24594673
    7. Endo-PDI is a novel, important mediator of AP-1-driven gene expression and endothelial angiogenic function. PMID: 24103565
    8. TXNDC5 has increased expression in many tumors that is involved in the proliferation and migration of tumor cells, acting as a tumor-enhancing gene. PMID: 24100949
    9. results suggest that TXNDC5 polymorphisms could be related to the development of HCC in the Korean male population PMID: 24023338
    10. Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46. PMID: 23713588
    11. Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis. PMID: 23326410
    12. s show that ERp46 is able to bind to a large pool of peptides containing aromatic and basic residues via all three of its catalytic domains (a(0), a and a'), though the a(0) domain may contain the primary binding site. PMID: 23376096
    13. crystal structure of the third catalytic domain of protein disulfide isomerase ERp46 (also known as protein disulfide isomerase A5 and TXNDC5) was determined to 2.0 A resolution PMID: 22505402
    14. TXNDC5 has a genetic effect on the risk of rheumatoid arthritis and ankylosing spondylitis PMID: 21801346
    15. Overexpression of the TXNDC5 protein is associated with non-small cell lung carcinoma. PMID: 21617212
    16. results suggest that TXNDC5 gene polymorphisms are associated with the development of nonsegmental vitiligo in the Korean population. PMID: 19906073
    17. TXNDC5 can promote the growth and proliferation of gastric cells. Silencing of TXNDC5 can restrain the growth and proliferation of gastric cancer cells. PMID: 20157732
    18. these results establish ERp46 as the first AdipoR1-specific interacting protein and suggest a role for ERp46 in adiponectin receptor biology and adiponectin signalling. PMID: 20074551
    19. ERp46 has specificity towards peroxiredoxin-4, a thioredoxin peroxidase. PMID: 19887585
    20. upregulation of TXNDC5 are involved in the early development of colorectal cancer PMID: 17895523
    21. Member of the protein disulphide isomerase family and highly expressed in endothelial cells. Protects endothelial cells from apoptosis under hypoxia. PMID: 12963716

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  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Protein disulfide isomerase family
  • 数据库链接：

    HGNC: 21073

    OMIM: 616412

    KEGG: hsa:81567

    STRING: 9606.ENSP00000369081

    UniGene: Hs.150837