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TXNDC17 Antibody

  • 货号：
    CSB-PA004860
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HL-60 Raji K562 SW480 A549 22RV-1 cells using TRP14 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9BRA2
  • 基因名：
    TXNDC17
  • 别名：
    TXNDC17 antibody; TXNL5Thioredoxin domain-containing protein 17 antibody; 14 kDa thioredoxin-related protein antibody; TRP14 antibody; Protein 42-9-9 antibody; Thioredoxin-like protein 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TRP14.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
  • 基因功能参考文献：
    1. found STAT3 could bind promoter region of TXNDC17 (-623 bp to -58 bp relative to the transcription start site (TSS)) for regulating its expression PMID: 26976343
    2. TXNDC17, through participation of BECN1, induces autophagy and consequently results in paclitaxel resistance in ovarian cancer PMID: 25607466
    3. The oxidoreductase activities of TRP14 thereby complement those of Trx1 and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols. PMID: 24778250
    4. TRP14 is a thioredoxin-related protein with roles in tumor necrosis factor-alpha signaling pathways PMID: 14607843
    5. TRP14 is a thioredoxin-related protein of 14 kDa PMID: 14607844
    6. Data report the crystal structure of human thioredoxin-related protein 14 determined at 1.8-angstrom resolution. PMID: 15355959
    7. LC8 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state. PMID: 18579519

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Thioredoxin family
  • 组织特异性：
    Ubiquitously expressed in cell lines.
  • 数据库链接：

    HGNC: 28218

    KEGG: hsa:84817

    STRING: 9606.ENSP00000250101

    UniGene: Hs.408236