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TUBA4A Antibody

  • 货号：
    CSB-PA025313GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P68366
  • 基因名：
  • 别名：
    Alpha-tubulin 1 antibody; ALS22 antibody; B ALPHA 1 antibody; bA408E5.3 antibody; H2 ALPHA antibody; Hum a tub1 antibody; Hum a tub2 antibody; LIS3 antibody; MGC171407 antibody; MGC55332 antibody; TBA4A_HUMAN antibody; Testis-specific alpha-tubulin antibody; TUBA1 antibody; TUBA1A antibody; tuba1l antibody; Tuba4a antibody; Tubulin alpha 1 chain antibody; Tubulin alpha antibody; Tubulin alpha-1 chain antibody; tubulin alpha-1B chain antibody; Tubulin alpha-4A chain antibody; Tubulin H2-alpha antibody; Tubulin, alpha 1 (testis specific) antibody; tubulin, alpha 1, like antibody; Tubulin, alpha 4a antibody; Tubulin, alpha, testis-specific antibody; Tubulin, alpha-1 antibody
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TUBA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能参考文献：
    1. Data indicate a microRNA-1825/TBCB/TUBA4A pathway as a putative pathogenic cascade in both familial ALS (fALS) and both sporadic (sALS). PMID: 30030593
    2. The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset. PMID: 28478440
    3. alphaTubulin expression might be an independent prognostic factor for pancreatic cancer after surgical resection PMID: 27447976
    4. Its mutations were seen in patients with ALS and frontotemporal dementia. PMID: 28069311
    5. TUBA4A mutations are not associated with FTD. PMID: 26675813
    6. In conclusion, our current results did not find an association between TUBA4A and ALS in Chinese patients, and further studies will be required. PMID: 26465396
    7. This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis. PMID: 25893256
    8. Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin cytoskeleton mediated by binding Tau protein. PMID: 26103986
    9. TUBA4A mutants destabilize the microtubule network, diminishing its repolymerization capability PMID: 25374358
    10. TUBA4A is significantly increased in spermatazoa from men with azoospermia. PMID: 24268707
    11. The results suggested that cytoskeletal alterations in the amygdala determined by tubulin seem to be involved in the pathophysiology of drug addiction PMID: 20686780
    12. Subunits of alphaB crystallin that exchange dynamically with the alphaB crystallin complex can interact with tubulin subunits to regulate the equilibrium between tubulin and microtubules. PMID: 20668689
    13. increased levels in paclitaxel-resistant breast cancer cells PMID: 12054644
    14. Some protein-protein interactions in rafts were disrupted in 3-nitrotyrosine-containing proteins, e.g. caveolin-1 was dissociated from a complex with flotillin-1 and alpha-tubulin. PMID: 15934946
    15. Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions. PMID: 16039987
    16. These results provide the first characterisation of endogenously nitrated tubulin from human tumour samples. PMID: 16257120

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  • 相关疾病：
    Amyotrophic lateral sclerosis 22, with or without frontotemporal dementia (ALS22)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 数据库链接：

    HGNC: 12407

    OMIM: 191110

    KEGG: hsa:7277

    STRING: 9606.ENSP00000248437

    UniGene: Hs.75318