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TUBA1B Antibody

  • 货号：
    CSB-PA04189A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TUBA1B antibody at 12 μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 51, 38 kDa
      Observed band size: 51, 34, 75 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA04189A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA04189A0Rb at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA04189A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TUBA1B Polyclonal antibody
  • Uniprot No.：
    P68363
  • 基因名：
  • 别名：
    ta 2b antibody; Alpha tubulin antibody; Alpha-tubulin ubiquitous antibody; beta Ib tubulin antibody; CDCBM5 antibody; CDCBM6 antibody; fd02b12 antibody; K ALPHA 1 antibody; M40 antibody; OK/SW-cl.56 antibody; TBA1B_HUMAN antibody; TUBA1B antibody; TUBB1 antibody; TUBB2 antibody; TUBB5 antibody; tubulin alpha 1b antibody; Tubulin alpha-1B chain antibody; Tubulin alpha-ubiquitous chain antibody; Tubulin beta 1b antibody; Tubulin beta 2A antibody; tubulin beta 2A class IIa antibody; Tubulin beta antibody; tubulin beta chain antibody; tubulin beta class I antibody; tubulin beta-1 chain antibody; tubulin beta-2A chain antibody; tubulin beta-5 chain antibody; Tubulin K-alpha-1 antibody; tubulin; alpha; ubiquitous antibody; tubulin; beta 2A class IIa antibody; tubulin; beta polypeptide 2 antibody; tubulin; beta polypeptide antibody; tubulin; beta; class IIA antibody; wu:fd02b12 antibody; zgc:55461 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Tubulin alpha-1B chain protein (29-310AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TUBA1B Antibody (CSB-PA04189A0Rb)，的标记方式是Non-conjugated。对于TUBA1B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA04189B0Rb TUBA1B Antibody, HRP conjugated ELISA
    FITC CSB-PA04189C0Rb TUBA1B Antibody, FITC conjugated
    Biotin CSB-PA04189D0Rb TUBA1B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能参考文献：
    1. Data show that retinal endothelial cells (HREC) treated with low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) exhibit a rapid increase in the amount and distribution of acetylated alpha-tubulin. PMID: 27613088
    2. The C-terminal tail from the tubulin beta I isotype, but not the beta III isotype, formed contacts in the putative binding site of a recently discovered antineoplastic peptide that disrupts microtubule formation in glioma cells. PMID: 28290671
    3. TUBA1B/ESR1 gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis. PMID: 26676054
    4. Taken together our data provide valuable information regarding the interaction of CK1delta and a-tubulin and a novel approach for the development of pharmacological tools to inhibit proliferation of cancer cells. PMID: 26996302
    5. Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia. PMID: 24760594
    6. NAD-dependent regulation of alpha-tubulin acetylation is mediated by SIRT2. PMID: 24814981
    7. Data indicate that the derivatives exhibited much better potency to inhibit tubulin polymerization but a decreased activity to inhibit Hsp27 chaperone function. PMID: 23767669
    8. Increased TUBA1B expression is associated with poor overall survival in hepatocellular carcinoma. PMID: 23625295
    9. ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling that affects migration and EMT through alpha-tubulin interaction and acetylation PMID: 23235160
    10. TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types. PMID: 21881916
    11. the ethyl acetate extract of Lactuca sativa induced HL-60 cell death, which correlated with the acetylation of alpha-tubulin. PMID: 20204303
    12. Confocal microscopic analyses showed co-localization of the TaSP protein with alpha-tubulin and reciprocal immuno-co-precipitation experiments demonstrated an association of TaSP with alpha-tubulin in vivo. PMID: 20162433
    13. This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
    14. increased levels in paclitaxel-resistant breast cancer cells PMID: 12054644
    15. Candidate gene K-ALPHA-1 expression in malignant and non-malignant prostate tissue samples after microdissection. PMID: 17628775
    16. accumulation of alpha-synuclein might contribute to the pathogenesis of PD and other Lewy body diseases by promoting alterations in parkin and tubulin solubility PMID: 18195004
    17. N-terminal sequencing and blastx analysis as well as blocking with K-alpha1 tubulin-specific Ab identified the epithelial Ag as K-alpha1 tubulin[K-alpha1 tubulin] PMID: 18354170
    18. These results imply that MeCP2 is involved in the regulation of neuronal alpha-tubulin and add molecular evidence that reversal of the effects of MeCP2 deficiency is achievable PMID: 19174478
    19. Increased expression of centrosomal TUBA1B in atypical ductal hyperplasia and carcinoma of the breast is reported. PMID: 19215229
    20. alpha-tubulin interacted with ARL7. PMID: 19409876
    21. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 数据库链接：

    HGNC: 18809

    OMIM: 602530

    KEGG: hsa:10376

    STRING: 9606.ENSP00000336799

    UniGene: Hs.524390