Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. TTI1 Antibody

TTI1 Antibody

  • 货号：
    CSB-PA012188LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA012188LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA012188LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA012188LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TTI1 Polyclonal antibody
  • Uniprot No.：
    O43156
  • 基因名：
  • 别名：
    TTI1 antibody; KIAA0406 antibody; SMG10 antibody; TELO2-interacting protein 1 homolog antibody; Protein SMG10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human TELO2-interacting protein 1 homolog protein (692-858AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TTI1 Antibody (CSB-PA012188LA01HU)，的标记方式是Non-conjugated。对于TTI1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA012188LB01HU TTI1 Antibody, HRP conjugated ELISA
    FITC CSB-PA012188LC01HU TTI1 Antibody, FITC conjugated
    Biotin CSB-PA012188LD01HU TTI1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
  • 基因功能参考文献：
    1. IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program. PMID: 24657168
    2. TTI1 and TTI2 protect cells from spontaneous DNA damage, and are required for the establishment of the intra-S and G2/M checkpoin PMID: 20810650
    3. Data show that that knockdown of either Tti1 or Tel2 causes disassembly of mTORC1 and mTORC2. PMID: 20427287
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Tti1 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 29029

    OMIM: 614425

    KEGG: hsa:9675

    STRING: 9606.ENSP00000362546

    UniGene: Hs.655481