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  4. TTF2 Antibody

TTF2 Antibody

  • 货号：
    CSB-PA120090
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA120090(TTF2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UNY4
  • 基因名：
  • 别名：
    F2 antibody; Factor 2 antibody; Factor2 antibody; HuF 2 antibody; HuF2 antibody; Human factor 2 antibody; Lodestar homolog antibody; Lodestar protein antibody; RNA polymerase II termination factor antibody; Transcription release factor 2 antibody; Transcription termination factor 2 antibody; Transcription termination factor RNA polymerase II antibody; TTF2 antibody; TTF2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human TTF2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:5-1:20
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
  • 基因功能参考文献：
    1. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing PMID: 12927788
    2. TTF2 is the only ATP-dependent termination activity associated with Pol II transcription elongation complexes, is largely unaffected by template position, and is impervious to the phosphorylation state of the polymerase. PMID: 15125840
    3. Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes. PMID: 15467445
  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 数据库链接：

    HGNC: 12398

    OMIM: 604718

    KEGG: hsa:8458

    STRING: 9606.ENSP00000358478

    UniGene: Hs.32333